PMID: 19920699Oct 1, 1995Paper

Basic sciences in clinical glaucoma: steroids, ocular hypertension, and glaucoma

Journal of Glaucoma
A F Clark

Abstract

Glucocorticoids (GC) can regulate aqueous humor outflow and have often been associated with primary open angle glaucoma (POAG). The ocular or systemic administration of glucocorticoids can cause the elevation of intraocular pressure by increasing aqueous humor outflow resistance via morphological and biochemical changes in the trabecular meshwork (TM). The ability of glucocorticoids to induce ocular hypertension is dependent on individual responsiveness, the potency of the glucocorticoid, the route of administration, and the duration of treatment. Glucocorticoid-induced ocular hypertension occurs not only in humans, but also in rabbits, cats, dogs, and nonhuman primates. Glucocorticoids have a multitude of effects on trabecular meshwork cells causing changes in TM protein expression, cytoskeletal organization, extracellular matrix deposition, cell shape, and cell function. Many of these changes in the TM may be responsible for the generation of glucocorticoid-induced ocular hypertension. There have been several reports of increased cortisol levels, altered cortisol metabolism, and differential glucocorticoid responsiveness in patients with ocular hypertension and POAG. However, there is as yet no clear evidence for a causal rol...Continue Reading

Citations

Mar 21, 2001·Pharmacogenomics·H T Steely, A F Clark
Aug 16, 2018·Journal of Cataract and Refractive Surgery·Jesus Cabral-MaciasAlejandro Navas
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A F ClarkE M Stone
Sep 10, 2020·Drug Delivery and Translational Research·Sherif A GaballaHamdy Abdelkader

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