Basic Skin Care and Topical Therapies for Atopic Dermatitis: Essential Approaches and Beyond

Journal of Investigational Allergology & Clinical Immunology
A Sala-CunillSkin Allergy Committee of Spanish Society of Allergy and Clinical Immunology (SEAIC)

Abstract

Atopic dermatitis (AD) is a recurrent and chronic skin disease characterized by dysfunction of the epithelial barrier, skin inflammation, and immune dysregulation, with changes in the skin microbiota and colonization by Staphylococcus aureus being common. For this reason, the therapeutic approach to AD is complex and should be directed at restoring skin barrier function, reducing dehydration, maintaining acidic pH, and avoiding superinfection and exposure to possible allergens. There is no curative treatment for AD. However, a series of measures are recommended to alleviate the disease and enable patients to improve their quality of life. These include adequate skin hydration and restoration of the skin barrier with the use of emollients, antibacterial measures, specific approaches to reduce pruritus and scratching, wet wrap applications, avoidance of typical AD triggers, and topical anti-inflammatory drugs. Anti-inflammatory treatment is generally recommended during acute flares or, more recently, for preventive management. Nevertheless, the selection of the pharmacologic agent, as well as its potency, duration, and frequency of application must be in accordance with the severity of the disease and the distribution and type of...Continue Reading

Citations

Aug 25, 2019·American Journal of Clinical Dermatology·Anna PothmannPeter Elsner
Jul 3, 2021·International Journal of Molecular Sciences·Jiun-Wen Guo, Shiou-Hwa Jee

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