Basic studies for the development of anticancer, antidementia, and taste modifier drugs

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Kazuyasu Nakaya

Abstract

We developed various types of differentiation- and apoptosis-inducing agents against tumor cells and also studied the function and structure of synucleins and taste modifiers. Differentiation- and apoptosis-inducing agents are classified into DNA-damaging agents, Na(+), K(+)-ATPase inhibitors, agents affecting the redox states of tumor cells, agents affecting signal transduction pathways, isoprenoid compounds, and ATP-noncompetitive tyrosine kinase inhibitors. These include camptothecin, etoposide, cisplatin, transplantin, bufalin, arsenic trioxide, costunolide, C(2)- ceramide, daidzein, geranylgeranylacetone, geranylgeraniol, vitamin K(2), sophoranone, and beta-hydroxyisovalerylshikonin. The mechanisms of action of these differentiation- and apoptosis-inducing agents are described. The structure and function of synucleins are also reviewed for the development of potential antidementia agents. In addition, the structures of three purified taste modifiers are described.

References

Sep 1, 1977·Chemical & Pharmaceutical Bulletin·U SankawaH Otsuka
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Jul 31, 1991·Biochemical and Biophysical Research Communications·L S ZhangY Kuroiwa
Sep 20, 1991·Biochimica Et Biophysica Acta·H IgetaY Kurihara
Dec 1, 1990·Journal of Neurochemistry·S NakajoY Nakamura
Jan 15, 1990·Biochemical and Biophysical Research Communications·S ChouY Nakamura
Jan 1, 1989·Journal of Cell Science. Supplement·D M GloverM H Leibowitz
Jun 15, 1989·Cancer·M J Wizenberg
Dec 1, 1969·Journal of Cellular Physiology·Y Ichikawa
Oct 15, 1981·Biochemical and Biophysical Research Communications·C MiyauraT Suda
Aug 1, 1995·British Journal of Haematology·F MentzJ L Binet
Sep 8, 1995·The Journal of Biological Chemistry·A N Akopian, J N Wood
Jan 1, 1995·Journal of Biochemistry·H OhizumiK Nakaya
Dec 15, 1994·Biochemical and Biophysical Research Communications·I SakaiK Nakaya
Jul 1, 1994·Journal of Cellular Physiology·S NumazawaY Kuroiwa
Apr 15, 1994·Cancer·J F KerrB V Harmon
May 23, 1994·FEBS Letters·R JakesM Goedert
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K UédaT Saitoh
Jan 17, 1993·Biochimica Et Biophysica Acta·Y OnishiH Kizaki

❮ Previous
Next ❯

Citations

Oct 7, 2021·International Journal of Toxicology·Satoru AsamiTakashi Suzuki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis