Basic thermoanalytical studies of insoluble collagen matrices

Biomaterials
W Friess, G Lee

Abstract

Insoluble collagen has been utilized as a base material for parenteral drug carrier systems. Information on its physicochemical properties was obtained by focussing on thermoanalytical methods. On the way from the raw material to the matrices, the acidic aqueous dispersion represents an important intermediate state. DSC and FTIR revealed its complete denaturation at 43 degrees C. Dense homogeneous collagen matrices were prepared by air-drying at 25 degrees C and became denatured at 103.5 degrees C, far above normal storage temperatures. Dielectrical Thermal Analysis demonstrated transitions in the dielectrical storage and loss moduli, reflecting the dissipation of electrical energy and increased molecular mobility caused by collapse of the triple helical structure. Cross-linking of the collagen dispersion with glutaraldehyde induced no alteration in the thermoanalytical properties of dry matrices. However, in the swollen state, after incubation of the devices in phosphate buffer the transition temperature increased from 50 to 70 degrees C as cross-linking was intensified. This indicated stronger interactions between the collagen fibre structures. Dissolution tests with cytochrome c-loaded matrices showed that higher amounts of ...Continue Reading

References

Sep 1, 1990·Journal of Biomedical Materials Research·D L Gilbert, S W Kim
Apr 1, 1990·Biomaterials·K R Meade, F H Silver
Jan 1, 1989·Matrix : Collagen and Related Research·J KoppJ P Renou
Sep 1, 1988·Journal of Cataract and Refractive Surgery·S R UntermanH E Kaufman
Oct 1, 1986·Biopolymers·D G WallaceS B Wade
Jan 1, 1986·Journal of Biomedical Materials Research·F DeLustroJ M McPherson
Aug 1, 1973·Journal of Clinical Pharmacology·A L RubinM Dunn
Jan 1, 1982·Biomaterials·R F OliverR A Grant

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Citations

Nov 25, 1998·Journal of Biomedical Materials Research·F El FeninatI Stangel
Oct 24, 2009·Journal of Materials Science. Materials in Medicine·Robin S WaltonJan T Czernuszka
Oct 30, 2012·Journal of Materials Science. Materials in Medicine·Roman A Perez, Maria-Pau Ginebra
Nov 19, 2003·Advanced Drug Delivery Reviews·Zbigniew Ruszczak
Nov 19, 2003·Advanced Drug Delivery Reviews·M GeigerW Friess
Nov 6, 2003·International Journal of Biological Macromolecules·Leszek KubiszFeliks Jaroszyk
May 10, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·W Friess, M Schlapp
Jan 22, 2009·Journal of Biomaterials Science. Polymer Edition·D I ZeugolisG Attenburrow
Apr 3, 1999·Journal of Biomaterials Science. Polymer Edition·K Watanabe, Y Koyama
Nov 21, 2013·Journal of Materials Science. Materials in Medicine·Ulla KönigMichael Gelinsky
Dec 22, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Jochen BürckMurat Kazanci
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Shane D Frazier, Wil V Srubar
Jun 26, 2012·Acta Biomaterialia·S J KewR E Cameron
May 15, 2010·Acta Biomaterialia·N DavidenkoR E Cameron
Mar 5, 2016·Macromolecular Bioscience·Emilia I WisotzkiMareike Zink
Mar 11, 2008·Biochimica Et Biophysica Acta·N A DanilovV V Lunin
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·Yu-Chang TyanChia-Chieh Chen
Feb 3, 2007·Journal of Biomedical Materials Research. Part a·Lanti YangJan Feijen
Nov 10, 2012·Journal of Food Science·Chao ZhangXiaoyan Zhao
Nov 23, 2007·Biophysical Journal·Lanti YangJan Feijen
Jun 24, 2006·Journal of Endodontics·Steven R ArmstrongDavid H Pashley
Mar 4, 2008·Biomaterials·Dimitrios I ZeugolisMichael Raghunath
May 10, 2008·Journal of Biomedical Materials Research. Part a·Dimitrios I ZeugolisGeoffrey Attenburrow
May 7, 2014·Journal of the Science of Food and Agriculture·Huan YangHanjun Zhang
Jul 1, 1996·Pharmaceutical Development and Technology·W FriessM J Groves
Feb 18, 2014·Carbohydrate Polymers·Ivy KanungoBalachandran Unni Nair
Jul 10, 2012·International Journal of Biological Macromolecules·Aswathy KandamchiraNishter Nishad Fathima
Feb 22, 2011·International Journal of Biological Macromolecules·Tanong AewsiriHarry Gruppen
Jan 9, 2007·Biophysical Journal·Uwe FreudenbergCarsten Werner
Jul 5, 2011·Biophysical Journal·Laurent Bozec, Marianne Odlyha
Mar 10, 2016·Asian-Australasian Journal of Animal Sciences·Sulaiman Mad-AliSajid Maqsood
Dec 19, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mustafa UnalOzan Akkus

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