Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1'-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Suzanne M F JeurissenIvonne M C M Rietjens

Abstract

The effects of a basil extract on the sulfation and concomitant DNA adduct formation of the proximate carcinogen 1'-hydroxyestragole were studied using rat and human liver S9 homogenates and the human hepatoma cell line HepG2. Basil was chosen since it contains the procarcinogen estragole that can be metabolized to 1'-hydroxyestragole by cytochrome P450 enzymes. Basil extract addition to incubations of rat and human liver S9 homogenates with 1'-hydroxyestragole, the sulfotransferase cofactor PAPS, and 2'-deoxyguanosine resulted in a dose-dependent inhibition of N2-(trans-isoestragol-3'-yl)-2'-deoxyguanosine formation. Because the inhibition resembled the inhibition by the sulfotransferase inhibitor pentachlorophenol and since the inhibition was not observed in incubations with the direct electrophile 1'-acetoxyestragole it is concluded that the inhibition occurs at the level of the sulfotransferase mediated bioactivation step. Additional experiments in HepG2 cells revealed the same protective effect of basil extract in intact cells, demonstrating that the inhibitors are able to enter the cells. The results of this study suggest that bioactivation and subsequent adverse effects of 1'-hydroxyestragole might be lower in a matrix o...Continue Reading

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Citations

May 8, 2010·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·K E Appel, K Abraham
Aug 2, 2011·Food & Function·Suzanne J P L van den BergIvonne M C M Rietjens
Nov 19, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ans PuntIvonne M C M Rietjens
May 26, 2011·Expert Opinion on Drug Metabolism & Toxicology·Zhong-Ze FangLing Yang
Feb 4, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Olaf KelberKarin Kraft
Sep 25, 2010·Chemico-biological Interactions·Ivonne M C M RietjensMarelle G Boersma
Feb 2, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Benjamin SmithR Woodrow Setzer
Apr 20, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luka Kristanc, Samo Kreft
Feb 11, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Erryana MartatiIvonne M C M Rietjens
Sep 15, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wasma AlhusainyIvonne M C M Rietjens
Jul 9, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ala' A A Al-SubeihiIvonne M C M Rietjens
Aug 21, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suzanne J P L van den BergIvonne M C M Rietjens
Jun 6, 2018·Expert Opinion on Drug Metabolism & Toxicology·Piero SestiliCarmela Fimognari
Aug 27, 2019·Drug Metabolism Reviews·Bo Wen, Peter Gorycki

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