Basil oil is a promising skin penetration enhancer for transdermal delivery of labetolol hydrochloride

Drug Development and Industrial Pharmacy
Rahul JainRoop K Khar

Abstract

The present work investigates effectiveness of basil oil, a volatile oil containing alcoholic terpenes, as a potential penetration enhancer for improved skin permeation of labetolol hydrochloride (LHCl) with reference to camphor, geraniol, thymol, and clove oil. Saturation solubilities of LHCl were determined in water, vehicle (ethanol:water, 60:40 v/v) and vehicle containing 5% w/v terpenes. Comparable (P > 0.05) saturation solubilities were found suggesting an insignificant increase in LHCl flux across rat skin on account of thermodynamic activity. Permeation of LHCl in vehicle per se and in presence of 5% w/v enhancer was investigated by performing in vitro rat abdominal skin permeation studies using a side-by-side glass diffusion cell. Various parameters viz. steady state flux, permeability coefficient, lag time, partition coefficient, diffusion coefficient, and enhancement ratios (ER) were calculated from the permeation data. Basil oil produced the maximum enhancement (ER = 46.52) over neat vehicle, among all enhancers. Activation energies for LHCl permeation in water, vehicle per se and in presence of 5% w/v basil oil were found to be 23.16, 18.71, and 10.98 kcal/mole, respectively. Lowering of activation energy in presen...Continue Reading

References

Jan 1, 1991·Pharmaceutical Research·A C Williams, B W Barry
Feb 15, 1991·Annals of Internal Medicine
Aug 6, 1999·Drug Development and Industrial Pharmacy·D A Godwin, B B Michniak
Sep 21, 2000·Pharmaceutical Science & Technology Today·A NaikR H Guy
Nov 9, 2000·Drug Development and Industrial Pharmacy·V R Sinha, M P Kaur
Aug 18, 2001·Skin Pharmacology and Applied Skin Physiology·J Hadgraft
Jan 5, 2002·Drug Development and Industrial Pharmacy·E S ParkS C Chi
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit Kumar JainRamesh Panchagnula
May 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·H K VaddiS Y Chan
Nov 16, 2002·International Journal of Pharmaceutics·Cristina D RöpkeSilvia B M Barros
Dec 14, 2002·International Journal of Pharmaceutics·Amit Kumar Jain, Ramesh Panchagnula
Mar 22, 2003·Drug Development and Industrial Pharmacy·Y S R KrishnaiahP Bhaskar
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunil Thomas Kumar Narishetty, Ramesh Panchagnula
Jul 30, 2005·BMJ : British Medical Journal·Sean C Sweetman
Apr 1, 1979·British Journal of Clinical Pharmacology·J J McNeilD J Morgan

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Citations

Oct 6, 2012·Therapeutic Delivery·Sevgi Güngör, Yildiz Ozsoy
May 15, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weiyang ChenAlvaro Viljoen
Feb 18, 2012·Drug Development and Industrial Pharmacy·Geeta AggarwalS L Hari Kumar
Apr 8, 2011·Drug Development and Industrial Pharmacy·Abdul AhadAsgar Ali
Feb 25, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Abdul AhadMohd Mujeeb
May 9, 2015·Artificial Cells, Nanomedicine, and Biotechnology·Abdul AhadMohd Mujeeb
Dec 25, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Abdul AhadMohd Aqil
Jul 26, 2012·International Journal of Cosmetic Science·E ViciolleC Rosado
Jan 6, 2015·The Journal of Pharmacy and Pharmacology·Anna Herman, Andrzej P Herman
Dec 4, 2010·Drug Development and Industrial Pharmacy·Gurkishan ChadhaR Jayachandra Babu
Sep 15, 2011·Pharmaceutical Development and Technology·Geeta AggarwalS L Harikumar
Feb 1, 2014·Archives of Dermatological Research·Umesh K Patil, Richa Saraogi
Jun 26, 2009·Expert Opinion on Therapeutic Patents·Abdul AhadSushama Talegaonkar
Jul 27, 2021·International Journal of Dermatology·Kesrin AmraFateh Khan

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