PMID: 11333017May 3, 2001Paper

Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p

RNA
B DongRobert H Silverman

Abstract

RNase L and Ire1p are members of a superfamily of regulated endoribonucleases that play essential roles in mediating diverse types of cellular stress responses. 2'-5' oligoadenylates, produced in response to interferon treatment and viral double-stranded RNA, are necessary to activate RNase L. In contrast, unfolded proteins in the endoplasmic reticulum activate Ire1p, a transmembrane serine/threonine kinase and endoribonuclease. To probe their similarities and differences, molecular properties of wild-type and mutant forms of human RNase L and yeast Ire1p were compared. Surprisingly, RNase L and Ire1p showed mutually exclusive RNA substrate specificity and partially overlapping but not identical requirements for phylogenetically conserved amino acid residues in their nuclease domains. A functional model for RNase L was generated based on the comparative analysis with Ire1p that assigns novel roles for ankyrin repeats and kinase-like domains.

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Citations

Nov 13, 2012·Cell Reports·Qian FengFrank J M van Kuppeveld
Dec 12, 2003·Molecular and Biochemical Parasitology·Antonio M EstévezChristine Clayton
Sep 22, 2010·Quarterly Reviews of Biophysics·Wei Yang
Jun 5, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Babal K JhaRobert H Silverman
May 24, 2005·Nature Structural & Molecular Biology·Florence Le RoyStuart W Peltz
Feb 10, 2011·The Journal of Biological Chemistry·Kori VolkmannJohn B Patterson
Nov 6, 2007·Antioxidants & Redox Signaling·Hiderou Yoshida
Nov 23, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Hanna RennertRobert H Silverman
Dec 31, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Arindam ChakrabartiRobert H Silverman
Jun 23, 2004·European Journal of Biochemistry·Masayuki NakanishiYukio Kitade
Aug 10, 2012·Journal of Virology·Arindam ChakrabartiRobert H Silverman
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Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Krishnamurthy MalathiRobert H Silverman
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Aug 8, 2007·Cytokine & Growth Factor Reviews·Robert H Silverman
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Mar 31, 2015·Cell Host & Microbe·Arindam ChakrabartiRobert H Silverman

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