PMID: 6162862Apr 1, 1981Paper

Basis for the control of purine biosynthesis by purine ribonucleotides

The Journal of Clinical Investigation
M ItakuraE W Holmes

Abstract

An animal model was used to determine the basis for the increase in purine biosynthesis that results from hepatic depletion of purine nucleotides, such as seen in patients with type I glycogen storage disease or following fructose administration. Mice were injected intravenously with glucose or fructose, 2.5 mg/g of body weight, and the animals were killed at 0, 3, and 30 min following carbohydrate infusion. Fructose, but not glucose, administration led to a threefold increase in [14C]glycine incorporation into hepatic purine nucleotides documenting an increase in the rate of purine biosynthesis in the liver of fructose-treated animals. In the fructose, but not the glucose-treated animals, there was a reduction in the hepatic content of purine nucleotides that are inhibitory for amidophosphoribosyltransferase, the enzyme that catalyzes the first reaction unique to the pathway of purine biosynthesis. PP-ribose-P, an important metabolite in the control of purine biosynthesis, was increased 2,3-fold in liver following fructose, but not glucose administration. In conjunction with the decrease in inhibitory nucleotides and increase in PP-ribose-P 29% of amidophosphoribosyltransferase was shifted from the large inactive to the small ...Continue Reading

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Citations

Aug 1, 1986·Metabolism: Clinical and Experimental·M ItakuraK Yamashita
Jan 1, 1980·Advances in Enzyme Regulation·E W Holmes
Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R Itoh
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J E SeegmillerG K Radda
Jun 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P M HassounB L Fanburg
Sep 1, 1983·The Journal of Clinical Investigation·M E KingS B Howell
Sep 1, 1989·The Journal of Clinical Investigation·M A JohnsonI H Fox
Oct 1, 1986·The American Journal of Physiology·M ItakuraK Yamashita
Oct 1, 1991·Biochemical Medicine and Metabolic Biology·P BoerO Sperling

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