Basis of aldehyde dehydrogenase deficiency in Orientals: immunochemical studies

Alcohol
D P AgarwalH W Goedde

Abstract

While most Caucasians have two main isozymes of liver aldehyde dehydrogenase, in about 50% of Orientals the ALDH I isozyme is missing. This isozyme, which has a faster electrophoretic mobility, is predominantly present in mitochondria and has a relatively low Km for acetaldehyde. The inherent deficiency of ALDH I is responsible for the impaired acetaldehyde oxidation leading to facial flushing and other cardiovascular symptoms of alcohol sensitivity commonly observed in Japanese and Chinese. Antibodies raised against apparently homogeneous liver ALDH I and ALDH II isozymes did not show an immunological similarity between the two isozymes which do not share common subunits. While erythrocyte ALDH II is also immunologically distinct from hepatic ALDH I, it showed an immunological similarity with hepatic ALDH II. On isoelectric focusing in agarose gel followed by immunoelectrophoresis, at least 4 components with an anti-ALDH I antibody were detected in extracts from Caucasian and Oriental livers. In Japanese livers deficient in ALDH I activity, the prominent ALDH component was missing. Apparently, more than one gene is responsible for the synthesis of ALDH isozymes reacting with an antibody against ALDH I. A deletion in one of the...Continue Reading

References

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Citations

Jan 1, 1990·Pharmacology & Therapeutics·H W Goedde, D P Agarwal
Nov 3, 2005·Sangyō eiseigaku zasshi = Journal of occupational health·Yasuhiro KomiyaTakahiko Katoh
Aug 6, 2013·Alcoholism, Clinical and Experimental Research·Ching-Long LaiShih-Jiun Yin
Mar 24, 1999·Biological Psychiatry·A K Malhotra, D Goldman
Mar 26, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yoshiyuki YamagishiHiromasa Ishii
Feb 18, 2010·The Psychiatric Clinics of North America·Sarah M Hartz, Laura J Bierut
Jul 17, 2012·The American Journal of Pathology·Jacqueline C BouchardDaniel G Remick
Sep 14, 2010·Clinics in Laboratory Medicine·Sarah M Hartz, Laura J Bierut
Jul 1, 1998·Addiction Biology·K Iwahashi, H Suwaki
Jul 14, 2000·Nursing & Health Sciences·S A Corcoran-PerryS Cochrane
Dec 1, 1994·The Journal of Applied Bacteriology·J P Hodge, N R Krieg
Jan 1, 1990·Zeitschrift für Rechtsmedizin. Journal of legal medicine·R EckeyH W Goedde

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