PMID: 8467644Jan 1, 1993Paper

Basis of norgestomet action as a progestogen in cattle

Domestic Animal Endocrinology
R J MoffattM F Smith

Abstract

Norgestomet is the progestational component present in Syncro-Mate-B, which is used to synchronize estrus in cattle. In post-partum cows, luteal phases anticipated to be short following first ovulation are of normal length when cows are pretreated with norgestomet. Because Syncro-Mate-B is used experimentally as a progestogen to affect uterine function, these studies were conducted to investigate how norgestomet acts at the level of the uterus. Receptor binding assays and a sensitive estrogen bioassay in tissue culture were used to address the possibility that some effects of norgestomet might be mediated through interaction of this compound with steroid hormone receptors other than the progesterone receptor (rP). The source of receptors was high-speed cytosol, prepared from bovine uterine endometrium, which was obtained from cyclic cows. Results of single-point and complete competition analyses comparing norgestomet and progesterone indicated that norgestomet competed even more effectively than did progesterone for specific binding of [3H]progesterone to rP. Results of similar studies, which compared the abilities of norgestomet and diethylstilbestrol to compete with [3H]estradiol for binding by uterine endometrial estrogen re...Continue Reading

References

Aug 1, 1975·The Journal of Clinical Endocrinology and Metabolism·P L BallardJ D Baxter
Oct 1, 1990·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·W V WelshonsP F Ross
Nov 30, 1974·The Veterinary Record·D F Wishart, I M Young
Mar 1, 1980·Analytical Biochemistry·C Labarca, K Paigen
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Jan 1, 1981·Journal of Receptor Research·W B PankoM R Walters

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