PMID: 8469376Jan 4, 1993Paper

Basket-like interneurones in layer II of the entorhinal cortex exhibit a powerful NMDA-mediated synaptic excitation

Neuroscience Letters
R S Jones, E H Buhl

Abstract

Spiny stellate neurones of layer II of the entorhinal cortex (EC) provide the perforant path input to the dentate gyrus. Previous studies have shown that synaptic responses of these neurones are dominated by GABAergic inhibition. The present study describes intracellular recordings from 'fast-spiking' interneurones in layer II which may be the basis of the synaptic inhibition. Lucifer yellow fills of fast-spiking cells revealed neurones with a widespread axonal arborization forming basket-like complexes around unlabelled cells in layer II. Synaptic activation of the fast-spiking cells evoked long duration excitations which were mediated largely by NMDA receptors. A fast AMPA/kainate EPSP was also detectable. These neurones have morphological and physiological properties which make them well-suited to exert a widespread inhibitory control over the efferent output of layer II to the dentate gyrus.

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Citations

Jan 16, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kim FejginDaniel Klamer
Feb 13, 2001·The European Journal of Neuroscience·T GloveliU Heinemann
Nov 11, 2008·Proceedings of the National Academy of Sciences of the United States of America·Steven MiddletonMark O Cunningham
Jun 12, 2008·Schizophrenia Bulletin·Anita K RoopunMiles A Whittington
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Menno P WitterKally C O'Reilly
Aug 31, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Babak TahvildariDavid A McCormick
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Houman Homayoun, Bita Moghaddam
Sep 22, 2009·Biological Psychiatry·Gregor LeichtChristoph Mulert
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Oct 31, 2006·Trends in Neurosciences·Menno P Witter, Edvard I Moser
Aug 7, 2007·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Etienne LabytFabrice Wendling
Oct 12, 2004·Trends in Neurosciences·James M TepperCharles J Wilson
Jun 16, 2015·British Journal of Pharmacology·D Lodge, M S Mercier
Mar 24, 2006·The European Journal of Neuroscience·Brigitta WernsmannAli Gorji

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