Basolateral amygdala and ventral hippocampus in stress-induced amplification of nicotine self-administration during reacquisition in rat

Psychopharmacology
Guoliang Yu, B M Sharp

Abstract

Cigarette smoking remains the leading cause of preventable morbidity and mortality in the USA, although only 3-5 % of quitters are successful for 6-12 months. Stress during abstinence increases the likelihood of relapse to smoking. We recently reported that repeated stress during abstinence from operant nicotine self-administration (SA) amplifies the reacquisition of nicotine SA and affects the diurnal intake of nicotine in rats. Herein, we sought to identify brain regions critical for the expression of stress-enhanced nicotine SA during reacquisition. Rats acquired nicotine SA (FR5) with virtually unlimited drug access (23 h/day). During abstinence (8 day), 30 min of restraint stress was applied on days 1, 3, 5, and 7. Beginning day 8, nicotine SA was reacquired over 5 days, and basolateral amygdala (BLA) was inactivated bilaterally or disconnected from nucleus accumbens core (NAcc). Similarly, ventral hippocampus (vHP) was inactivated or disconnected from BLA. Bilateral inactivation (muscimol + baclofen) of BLA or disconnection from NAcc abolished the stress-enhanced reacquisition of nicotine SA without affecting basal levels of nicotine SA. Similarly, bilateral inactivation of vHP or disconnection of vHP and BLA also abolish...Continue Reading

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Citations

May 26, 2017·Journal of Psychopharmacology·Parastoo JavadiZahra Ghasemzadeh
Sep 20, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Zamzuri IdrisJafri Malin Abdullah
Oct 3, 2015·Alcoholism, Clinical and Experimental Research·Angela R OzburnJohn C Crabbe
Dec 15, 2020·Drug and Alcohol Dependence·John R SmethellsMark G LeSage
Feb 15, 2021·Brain Structure & Function·James W M KangKevin A Keay

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