Basolateral amygdala lesions disrupt latent inhibitionin rats

Brain Research Bulletin
E CoutureauS Killcross

Abstract

Latent inhibition (LI) refers to the retardation of acquisition of conditioned responding produced by repeated non-reinforced preexposure to the conditioned stimulus (CS) prior to its pairing with the unconditioned stimulus (US) during conditioning. LI has recently been shown to depend upon the integrity of temporal lobe structures, including regions of the hippocampal formation such as the entorhinal cortex. The present study investigated the effects of excitotoxic lesions of another temporal lobe structure, the basolateral nucleus of the amygdala (BLA), on LI. LI was studied in a within-subjects appetitive conditioning preparation in which an auditory CS was paired with food US. In this procedure, preexposure to the CS results in slower acquisition of magazine approach behaviour. Lesions of the BLA reduced the effect of preexposure, disrupting LI. This result suggests that the BLA can play a crucial role in LI. The possible involvement of interactions between BLA and entorhinal cortex in LI is discussed.

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Citations

Apr 21, 2005·Behavioral Neuroscience·Jennifer A Davis, Thomas J Gould
Jan 15, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Segev Barak, Ina Weiner
Jul 8, 2005·Psychopharmacology·Anja Murschall, Wolfgang Hauber
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Apr 14, 2021·Current Biology : CB·Kauê Machado CostaGeoffrey Schoenbaum
Mar 24, 2009·Learning & Memory·Yannick SevelingesGuillaume Ferreira

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