Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats

Learning & Memory
Mary L HuffRyan T LaLumiere

Abstract

The basolateral amygdala (BLA) modulates memory consolidation for a variety of types of learning, whereas other brain regions play more selective roles in specific kinds of learning suggesting a role for differential consolidation via distinct BLA pathways. The ventral hippocampus (VH), an efferent target of the BLA, has been suggested to selectively process emotion-related learning, yet whether the BLA → VH pathway modulates memory consolidation, and does so in a learning-specific manner, is unknown. To address this issue, the BLA of male Sprague-Dawley rats was bilaterally transduced to express either ChR2(E123A) or eArchT3.0. Fiber optic probes were implanted in the VH to provide illumination of BLA axons. Rats then underwent a modified contextual fear conditioning task permitting separation of context and footshock learning. On day 1, rats received 3 min of pre-exposure to the apparatus. On day 2, rats were placed into the apparatus, received an immediate footshock, and quickly removed. Retention was tested on day 4. Optical stimulation of the BLA → VH pathway following footshock, but not context, training using trains of 40-Hz light pulses enhanced retention. Continuous optical inhibition of this pathway for 15 min startin...Continue Reading

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Citations

Apr 20, 2017·Pharmacological Reviews·Ryan T LaLumiereChrista K McIntyre
Jun 27, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kylie A HuckleberryMichael R Drew
May 23, 2019·Frontiers in Behavioral Neuroscience·Nathan S Ahlgrim, Joseph R Manns
Oct 3, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Krista L WahlstromRyan T LaLumiere
Jul 19, 2019·Neuron·Drew B HeadleyDenis Paré
Feb 25, 2018·Neurobiology of Learning and Memory·Gürsel Çalışkan, Oliver Stork
Apr 3, 2021·Genes, Brain, and Behavior·Lisa R GoldbergThomas J Gould
Jul 25, 2021·Neurobiology of Learning and Memory·Rafael RoeslerChrista K McIntyre
Oct 30, 2021·Frontiers in Cellular Neuroscience·Priyodarshan GoswameeA Rory McQuiston

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