PMID: 9446827Apr 4, 1998Paper

Basolateral distribution of caveolin-1 in the kidney. Absence from H+-atpase-coated endocytic vesicles in intercalated cells

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
S BretonD Brown

Abstract

In kidney epithelial cells, a variety of physiological processes are dependent on the active recycling of membrane proteins between intracellular vesicles and the cell surface. Although clathrin-mediated endocytosis occurs in several renal cell types, endocytosis can also occur by non-clathrin-coated vesicles, including pinocytotic structures known as caveolae that contain a novel coat protein, caveolin. Exo- and endocytosis of a vacuolar H+-ATPase in intercalated cells also occurs via specialized "coated" vesicles that do not contain clathrin. The aim of this study was to localize caveolin in the kidney and, in addition, to determine whether it could be a component of the H+-ATPase recycling process. Using an antibody against the alpha- and beta-isoforms of caveolin-1, our immunocytochemical data show a marked heterogeneity in the cellular expression of this isoform of caveolin in kidney. In contrast, caveolin-3 was not detectable in renal epithelial cells. Caveolin-1 was abundant in endothelial cells and smooth muscle cells and was present in the parietal cells of Bowman's capsule. Distal tubule cells, connecting tubule cells, and collecting duct principal cells exhibited marked punctate basolateral staining, corresponding to...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R D NelsonS Gluck
Oct 1, 1992·Journal of the American Society of Nephrology : JASN·D Brown, G L Waneck
Feb 1, 1990·The American Journal of Physiology·W I LencerD Brown
Feb 21, 1992·Cell·K G RothbergR G Anderson
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S L AlperD Brown
Apr 1, 1986·The American Journal of Physiology·D Brown, L Orci
Dec 1, 1974·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I W McLean, P K Nakane
Nov 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·R C WagnerM W Bitensky
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M MurataK Simons
Aug 1, 1993·Current Opinion in Cell Biology·R G Anderson
Jan 1, 1995·Molecular Membrane Biology·M P LisantiM Sargiacomo
Jun 30, 1995·The Journal of Biological Chemistry·S LiM P Lisanti
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M ChunH F Lodish
Jul 1, 1994·The Journal of Cell Biology·W J ChangR G Anderson
Mar 1, 1993·The Journal of Cell Biology·T Fujimoto
Jun 24, 1996·FEBS Letters·T V Kurzchalia, R G Parton
Aug 1, 1996·Current Opinion in Cell Biology·R G Parton
Sep 1, 1996·The American Journal of Physiology·C MirreA Le Bivic
Aug 1, 1993·Trends in Cell Biology·B van DeursS H Hansen

❮ Previous
Next ❯

Citations

Jul 20, 2006·Acta Neuropathologica·V BarresiG Barresi
Jun 18, 2003·Urologic Oncology·Rafael CarrionMichael B Morgan
Mar 18, 2000·Kidney International·D Brown, S Breton
Aug 8, 2002·Kidney International·Hidetsuna WatanabeRobin A Felder
Nov 19, 2010·The Journal of Biological Chemistry·Seung-Kuy ChaR Tyler Miller
Feb 28, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Valeria BarresiGaetano Barresi
Dec 1, 2004·Kidney International·Peiying YuPedro A Jose
May 24, 2013·Journal of Virology·Sharof M TugizovJoel M Palefsky
Feb 4, 2011·American Journal of Physiology. Renal Physiology·John J GildeaRobin A Felder
Oct 29, 2010·American Journal of Physiology. Renal Physiology·Zhenjie ZhuangDennis Brown
Jun 27, 2008·American Journal of Physiology. Renal Physiology·Pia WelkerSebastian Bachmann
May 19, 2009·The Journal of Experimental Biology·Dennis BrownVladimir Marshansky
May 14, 2011·Journal of the American Society of Nephrology : JASN·Dao-Hong LinWen-Hui Wang
Dec 20, 2003·American Journal of Physiology. Cell Physiology·Jaafar El-AnnanVladimir Marshansky
May 27, 2004·The Journal of Biological Chemistry·Mara FerrandiPatrizia Ferrari
Jun 28, 2007·Cancer·Ila TamaskarMing Zhou
Apr 28, 2007·Virchows Archiv : an International Journal of Pathology·Yoshihide FujigakiAkira Hishida
Dec 14, 2004·The Journal of Biological Chemistry·Valérie BeaulieuSylvie Breton
Jul 9, 2005·The Journal of Biological Chemistry·Debbie WilloughbyDermot M F Cooper
Apr 8, 2015·Journal of the American Society of Nephrology : JASN·Lijun WangWenhui Wang
Oct 28, 2005·American Journal of Physiology. Cell Physiology·Rosalia C MoraEnrique Rodriguez-Boulan
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Sylvie Breton, Dennis Brown
Nov 4, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pia WelkerSebastian Bachmann
Oct 18, 2013·American Journal of Physiology. Renal Physiology·Teodor G PăunescuDennis Brown
Sep 3, 2013·Physiology·Sylvie Breton, Dennis Brown
Jul 7, 2007·Physiological Reviews·Debbie Willoughby, Dermot M F Cooper
Apr 23, 2004·American Journal of Physiology. Cell Physiology·Ruben M SandovalBruce A Molitoris
Dec 13, 2019·Nature·Craig RamirezDafna Bar-Sagi
Jul 5, 2003·Physiological Reviews·Pamela L Tuma, Ann L Hubbard
May 9, 2002·American Journal of Physiology. Renal Physiology·Tian-Xiao SunDennis Brown
Sep 27, 2003·Acta Physiologica Scandinavica·M VoldstedlundE I Christensen
May 12, 2000·American Journal of Physiology. Renal Physiology·S BretonD Brown

❮ Previous
Next ❯

Related Concepts

Related Feeds

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.