Basonuclin: a novel mammalian maternal-effect gene

Development
Jun MaHung Tseng

Abstract

Basonuclin is a zinc-finger protein found in abundance in oocytes. It qualifies as a maternal-effect gene because the source of pre-implantation embryonic basonuclin is maternal. Using a transgenic-RNAi approach, we knocked down basonuclin specifically in mouse oocytes, which led to female sub-fertility. Basonuclin deficiency in oocytes perturbed both RNA polymerase I- and II-mediated transcription, and oocyte morphology was affected (as evidenced by cytoplasmic and cell surface abnormalities). Some of the affected oocytes, however, could still mature to and arrest at metaphase II, and be ovulated. Nevertheless, fertilized basonuclin-deficient eggs failed to develop beyond the two-cell stage, and this pre-implantation failure accounted for the sub-fertility phenotype. These results suggest that basonuclin is a new member of the mammalian maternal-effect genes and, interestingly, differs from the previously reported mammalian maternal-effect genes in that it also apparently perturbs oogenesis.

References

Jul 1, 1989·Journal of Reproduction and Fertility·C L ChatotI Torres
May 1, 1994·Biology of Reproduction·G T ErbachJ D Biggers
Aug 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Schultz
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·S Iuchi, H Green
Oct 26, 2000·Nature·E ChristiansI J Benjamin
Oct 6, 2001·Biochemical and Biophysical Research Communications·P SvobodaR M Schultz
Dec 4, 2001·Journal of Reproductive Immunology·Jurrien Dean
Mar 26, 2003·Developmental Biology·Paula SteinRichard M Schultz
Apr 26, 2003·Science·Kathleen H BurnsMartin M Matzuk
Oct 2, 2003·Genome Biology·Douglas A HosackRichard A Lempicki
Dec 5, 2003·Current Biology : CB·Bernhard PayerM Azim Surani
Jan 13, 2004·Science·Andrew M FedoriwMarisa S Bartolomei
Jan 16, 2004·Developmental Cell·Toshio HamataniMinoru S H Ko
Feb 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Amandine Vanhoutteghem, Philippe Djian
Mar 20, 2004·Developmental Biology·Junying YuRichard M Schultz
Jul 30, 2004·Developmental Biology·Fanyi ZengRichard M Schultz
Aug 18, 2004·Cancer Research·Chunhua CuiHung Tseng
Jun 25, 2005·Developmental Biology·Fanyi Zeng, Richard M Schultz

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Citations

Jan 29, 2013·Molecular Aspects of Medicine·Lei LiJurrien Dean
Mar 29, 2007·Reproduction, Fertility, and Development·Xiang-Shun Cui, Nam-Hyung Kim
Dec 25, 2007·Reproduction, Fertility, and Development·Anilkumar BettegowdaGeorge W Smith
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Amandine Vanhoutteghem, Philippe Djian
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Amandine VanhoutteghemPhilippe Djian
Oct 20, 2011·The Journal of Biological Chemistry·Chia Lin ChangSheau Yu Teddy Hsu
Jun 23, 2009·Molecular Human Reproduction·T MaraldiA De Pol
Apr 7, 2010·The Journal of Clinical Investigation·Roger Gosden, Bora Lee
Jun 15, 2007·BMC Developmental Biology·Saurabh JoshiJurrien Dean
Aug 7, 2010·Biology Direct·Sucheta A GokhaleChetan J Gadgil
Feb 25, 2010·Development·Lei LiJurrien Dean
Sep 11, 2007·The Journal of Reproduction and Development·Naojiro MinamiSatoshi Tsukamoto
Sep 20, 2007·PloS One·Shengliang ZhangHung Tseng
Jan 29, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Piraye YurttasScott A Coonrod
Jun 12, 2013·Reproduction, Fertility, and Development·Hui PengYong Zhang
Feb 1, 2012·Médecine sciences : M/S·Françoise HervéPhilippe Djian
Aug 28, 2012·Animal Reproduction Science·Radek Malik, Petr Svoboda
Jul 12, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Linda BoldrupKarin Nylander
Mar 1, 2016·Mechanisms of Development·Amandine VanhoutteghemPhilippe Djian
Sep 29, 2015·The Journal of Reproduction and Development·Hui PengWenchang Zhang
Nov 12, 2014·Zygote : the Biology of Gametes and Early Embryos·Hui PengWenchang Zhang
Jul 20, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hung Tseng
Jan 24, 2012·Genesis : the Journal of Genetics and Development·Xiaohong ZhangHung Tseng
Aug 22, 2006·Biochemical and Biophysical Research Communications·Junwen WangHung Tseng
Mar 3, 2015·Animal Reproduction Science·M MoussaF Zeng
Feb 20, 2015·Reproduction, Fertility, and Development·Kun Zhang, George W Smith
Jul 8, 2015·Nature Communications·Maria Vera-RodriguezCarlos Simon
Mar 28, 2008·Developmental Biology·Petr SolcJan Motlik
Oct 27, 2007·Developmental Biology·Hideki IgarashiCarmen J Williams
Jul 22, 2014·Clinical and Experimental Reproductive Medicine·Kyeoung-Hwa Kim, Kyung-Ah Lee
Jun 21, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Hui PengWenchang Zhang
Feb 15, 2017·Journal of Cell Science·Claudia BaumannMaria M Viveiros
Aug 30, 2008·Biology of Reproduction·Kyeoung-Hwa KimKyung-Ah Lee

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