Basophil models of homeopathy: a sceptical view

Homeopathy : the Journal of the Faculty of Homeopathy
Madeleine Ennis

Abstract

This paper examines the activation and inhibition of activation of human basophils. After a brief description of human basophils, different methods to determine basophil activation are discussed with a special emphasis on the use of flow cytometric methods, as these circumvent the potential problems of assays based on the loss of colour by activated basophils. The activation of human basophils by ultra-high dilutions of anti-IgE is discussed. The majority of the paper describes the inhibition of basophil activation by ultra-high dilutions of histamine. The results from published papers are described and discussed. After over 20 years research trying to find out if high dilutions of histamine have a negative feedback effect on the activation of basophils by anti-IgE, what do we know? The methods are poorly standardized between laboratories - although the same is true for conventional studies. Certainly there appears to be some evidence for an effect - albeit small in some cases - with the high dilutions in several different laboratories using the flow cytometric methodologies. After standardization of a number of parameters, it is recommended that a multi-centre trial be performed to hopefully put an end to this "never-ending st...Continue Reading

References

Jul 1, 1992·The Journal of Allergy and Clinical Immunology·E F KnolD Roos
Jul 28, 1988·Nature·J MaddoxW W Stewart
Apr 1, 1988·British Journal of Clinical Pharmacology·B PoitevinJ Benveniste
Apr 16, 1987·Journal of Immunological Methods·J Sainte-Laudy
Jul 27, 1973·Nature·L M Lichtenstein, E Gillespie
Mar 1, 1993·International Journal of Bio-medical Computing·B HadjajJ Sainte Laudy
Mar 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Sainte-Laudy, P Belon
Jun 23, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Sainte-Laudy
Mar 22, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A D Crockard, M Ennis
Jul 27, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A D Crockard, M Ennis
Feb 18, 2003·Homeopathy : the Journal of the Faculty of Homeopathy·I LorenzJ Strube
Jan 7, 2004·Forschende Komplementärmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine·I LorenzJ Strube
Apr 24, 2004·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·P BelonF A C Wiegant
Jul 23, 2005·Complementary Therapies in Medicine·Adrian G GuggisbergPeter Heusser
May 18, 2006·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Sainte-Laudy, P Belon
Jul 14, 2006·International Archives of Allergy and Immunology·Jörg Kleine-TebbeBernhard F Gibbs
Jun 5, 2007·Complementary Therapies in Medicine·Claudia M WittStefan N Willich
Jun 6, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Paolo BellaviteAnita Conforti
Jul 13, 2007·International Journal of Immunopathology and Pharmacology·A W HauswirthP Valent
Jul 31, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Sainte-LaudyM Cogné
Mar 18, 2008·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Sainte-LaudyPh Belon
Mar 10, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·J Sainte-LaudyP Belon
May 7, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Salvatore ChirumboloPaolo Bellavite

❮ Previous
Next ❯

Citations

Jan 1, 2012·ISRN Toxicology·R M Kuzeff
Feb 5, 2010·Homeopathy : the Journal of the Faculty of Homeopathy·Peter Fisher
Dec 19, 2015·Homeopathy : the Journal of the Faculty of Homeopathy·Bernard Poitevin
Oct 26, 2010·Homeopathy : the Journal of the Faculty of Homeopathy·Domenico Mastrangelo
Aug 20, 2017·The Veterinary Record·P LeesM L Whitehead

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
P BelonF A Wiegant
Homeopathy : the Journal of the Faculty of Homeopathy
Fred Wiegant, Roeland Van Wijk
Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
P BelonF A Wiegant
© 2021 Meta ULC. All rights reserved