PMID: 58935Jul 1, 1976

Basophil-sensitizing antibody response to herpes simplex viruses in rabbits

The Journal of Immunology : Official Journal of the American Association of Immunologists
R P DayW E Rawls

Abstract

Antibodies to herpes simplex virus type 1 and type 2 were detected in the sera of rabbits by release of histamine from basophils sensitized in vitro with the sera. The time course of the appearance of the antibodies, the dose-response curve of the release of histamine in relation to antigen concentration, the sedimentation characteristics of the antibodies in sucrose gradients, and the ability to destroy the sensitizing capacity of the sera with heat suggest that the antibodies being assessed were of the IgE class. These antibodies were induced in animals injected intradermally, intramuscularly, and i.p. with live virus. The antibodies were detected 1 week after primary injection and a similar time course of antibody appearance was observed after a second or third injection. The same cross-reactivity between type 1 and type 2 virus observed with IgG antibody was also observed with IgE antibody.

Related Concepts

Antibodies, Viral
Antibody Formation
Basophils
Centrifugation, Density Gradient
Histamine Release
Immunoglobulin E
Herpesvirus 16, Cercopithecine

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.