Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism

Cell Reports
Xiaoman SunGeorge F Gao


A new influenza-like virus genome (H17N10) was recently discovered in bats and offers a new perspective about the origin and evolution of influenza viruses. The viral envelope glycoprotein hemagglutinin (HA) is responsible for influenza virus receptor binding, fusion, and entry into the cell; therefore, the structure and function of HA H17 was characterized. The 2.70 Å resolution crystal structure revealed that H17 has a typical influenza A virus HA fold, but with some special features, including a distorted putative sialic acid (SA) binding site and low thermostability. No binding to either the canonical human α2,6 SA-linkage or avian α2,3 SA-linkage receptor was observed. Furthermore, H17 glycan binding was not detected using a chip covering more than 600 glycans. Our results demonstrate that H17 is unique among characterized HAs and that the bat-derived influenza virus may use a different entry mechanism compared to canonical influenza viruses.


Mar 1, 1992·Microbiological Reviews·R G WebsterYoshihiro Kawaoka
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G M Air
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·John J SkehelD C Wiley
Apr 21, 1999·Trends in Microbiology·W Garten, H D Klenk
Aug 31, 2000·Annual Review of Biochemistry·John J Skehel, D C Wiley
Sep 22, 2001·Acta Crystallographica. Section D, Biological Crystallography·Randy J Read
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·Collaborative Computational Project, Number 4
May 1, 1997·Acta Crystallographica. Section D, Biological Crystallography·G N MurshudovE J Dodson
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Jul 4, 2008·Nature Structural & Molecular Biology·Stephen C Harrison
Feb 24, 2009·Nature Structural & Molecular Biology·Jianhua SuiWayne A Marasco
Mar 3, 2009·Science·Damian C EkiertIan A Wilson
May 28, 2009·Science in China. Series C, Life Sciences·Di LiuGeorge F Gao
Feb 4, 2010·Acta Crystallographica. Section D, Biological Crystallography·Paul D AdamsPeter H Zwart
Jun 12, 2010·The Journal of Biological Chemistry·Steven J Gamblin, John J Skehel
Jul 3, 2010·Science China. Life Sciences·George F Gao, Yeping Sun
Jan 5, 2011·Protein & Cell·Yi GuanGavin J D Smith
Jul 9, 2011·Science·Damian C EkiertJaap Goudsmit
Jul 13, 2011·Nature Reviews. Microbiology·Rafael A Medina, Adolfo García-Sastre
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Suxiang TongRuben O Donis
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Qing LiGeorge F Gao
Sep 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xueyong ZhuIan A Wilson


Mar 4, 2014·Trends in Microbiology·Ying WuGeorge F Gao
Sep 27, 2014·Viruses·Andrew Mehle
Nov 26, 2015·Virology·Junki MaruyamaAyato Takada
Aug 7, 2013·Science China. Life Sciences·ZhengLi Shi
Mar 8, 2016·Current Opinion in Virology·Linda BrunotteMartin Schwemmle
Nov 15, 2013·The Journal of General Virology·Thomas O EdingerSilke Stertz
Oct 29, 2013·Biochimica Et Biophysica Acta·Caroline M MairChristian Sieben
Sep 1, 2016·Annual Review of Virology·David T S Hayman
Oct 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Étori Aguiar MoreiraGert Zimmer
Feb 6, 2018·Nature Structural & Molecular Biology·Nicholas C Wu, Ian A Wilson
Dec 15, 2017·Journal of Virology·Hannah L TurkingtonBenjamin G Hale
Jul 24, 2014·Nature Communications·Mindaugas JuozapaitisMartin Schwemmle
Aug 8, 2018·Veterinary Sciences·Suresh V Kuchipudi, Ruth H Nissly
Aug 8, 2015·Journal of Virology·Hannah L TurkingtonBenjamin G Hale
Sep 15, 2017·The Journal of General Virology·Kevin CiminskiMartin Schwemmle
Sep 19, 2019·Nature Microbiology·Kevin CiminskiMartin Schwemmle
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Nicholas C Wu, Ian A Wilson
Jun 1, 2013·Emerging Microbes & Infections·Ying Wu, George F Gao
Feb 18, 2020·Virus Evolution·Weng M NgThomas A Bowden
Jun 26, 2020·Frontiers in Cellular and Infection Microbiology·Efstathios S Giotis
Feb 6, 2019·Scientific Reports·Masahiro SatoAyato Takada
Apr 17, 2020·PLoS Pathogens·Kevin CiminskiMartin Schwemmle

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