Bat hepadnaviruses and the origins of primate hepatitis B viruses

Current Opinion in Virology
Andrea RascheJan Felix Drexler

Abstract

The origin of primate HBV (family Hepadnaviridae) is unknown. Hepadnaviruses are ancient pathogens and may have been associated with old mammalian lineages like bats for prolonged time. Indeed, the genetic diversity of bat hepadnaviruses exceeds that of extant hepadnaviruses in other host orders, suggesting a long evolution of hepadnaviruses in bats. Strikingly, a recently detected New World bat hepadnavirus is antigenically related to HBV and can infect human hepatocytes. Together with genetically diverse hepadnaviruses from New World rodents and a non-human primate, these viruses argue for a New World origin of ancestral orthohepadnaviruses. Multiple host switches of bat and primate viruses are evident and bats are likely sources of ancestral hepadnaviruses acquired by primates.

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Citations

Apr 4, 2018·Cold Spring Harbor Perspectives in Medicine·Anna-Lena SanderJan Felix Drexler
May 11, 2018·ELife·Ben Krause-KyoraJohannes Krause
Aug 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrea RascheJan Felix Drexler
Mar 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Andrea RascheUNKNOWN Equid HBV Consortium
Jun 11, 2021·Frontiers in Microbiology·Stephen A LocarniniLilly K W Yuen
Aug 14, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Gang LuShoujun Li
Mar 19, 2019·Virology·Fang-Yuan NieYong-Zhen Zhang

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