BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine

Scientific Reports
Zhongyang LiuFuchu He

Abstract

Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new drug development, especially for the treatment of complex diseases is promising. However, owing to the TCM's diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). Its main functions include 1) TCM ingredients' target prediction; 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses; 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets; 4) comparison analysis of multiple TCMs. Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ's cardioprotective effects for the first time. BATMAN-TCM will contribute to the understanding...Continue Reading

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Citations

Nov 7, 2017·Nucleic Acids Research·Lin HuangChengping Wen
Oct 15, 2018·Journal of Cellular Physiology·Ning DingChuhong Zhu
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May 7, 2020·Biotechnology and Applied Biochemistry·Jian ChenYong-Bing Cao
Nov 30, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zehui HePingping Gan
Jul 1, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhenjie ZhuangZhanhua Liu
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Lin ZhouDisheng Tao
Oct 6, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Zhulin WuLisheng Peng
Jun 1, 2018·International Journal of Genomics·Yong WangGuoxun Chen
Jul 4, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Chang FanHui Jiang
Aug 28, 2020·Frontiers in Pharmacology·Wenfeng ZhangChanggang Sun
Sep 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yongming ShuaiFanhui Zeng
Jul 11, 2018·International Journal of Molecular Sciences·Minyu ZhangHongjun Yang

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Datasets Mentioned

BETA
DB01364

Methods Mentioned

BETA
interaction prediction

Clinical Trials Mentioned

NCT00797953
NCT00854087

Software Mentioned

BATMAN
R
Pathview
TCM
- Analysis Tool
SIDER
QSYQ
Cytoscape
RAAS

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