Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL

Biochemical Pharmacology
Cheol Kyu ParkHong-Hee Kim

Abstract

Osteoclasts are cells that have a specialized role for bone resorption and are responsible for many bone diseases such as osteoporosis. As herbal products are invaluable sources in discovery of compounds for new therapies, we sought to identify compounds efficacious in suppressing osteoclastogenesis from medicinal plants that have been implicated for treatment of osteoporotic conditions. Bavachalcone was isolated from Psoralea corylifolia, and its effects on osteoclast differentiation were evaluated with primary cultures of osteoclast precursor cells. In addition, the molecular mechanism of action was investigated. Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, by RANKL was also suppressed by bavachalcone. In conclusion, bavachalcone inhibits osteoclastogenesis by interfering with the ERK and Akt signaling pathways and the induction of c-Fos and NFATc1 during differentiation. Our resu...Continue Reading

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Citations

May 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Chien-Hung LaiYu-Hui Tsai
Jan 27, 2015·International Immunopharmacology·Naoki KoideKazuo Umezawa
Jul 14, 2012·Bioscience, Biotechnology, and Biochemistry·Kentaro Tsuji-Naito, Ralph W Jack
Sep 29, 2011·Chemico-biological Interactions·Leilei BaoQiaoyan Zhang
Feb 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Min JiaLu-Ping Qin
Mar 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun-Tao CheChristopher Wai Kei Lam
May 16, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Lina ShanXianbao Shi
Jul 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yanqi DangJin-Wen Xu
Mar 9, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mithun GhoshBeong Ou Lim
Jun 9, 2018·International Journal of Molecular Sciences·Hyejin LeeJae-Ha Ryu
Feb 29, 2020·International Journal of Molecular Sciences·Yeongeun HanJae-Ha Ryu
Jul 14, 2020·Oxidative Medicine and Cellular Longevity·Yi-Ting ZhouJin-Wen Xu

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