PMID: 11906913Mar 22, 2002Paper

Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis

Biology of Reproduction
Lonnie D RussellC M Knudson

Abstract

Bax is a multidomain, proapoptotic member of the Bcl-2 family that is required for normal spermatogenesis in mice. Despite its proapoptotic function, previous results found that Bax-deficient mature male mice demonstrate increased cell death and dramatic testicular atrophy. The present study examined the role of Bax during the normal development of the testis to determine whether the increased cell death in mature mice could be explained by decreased apoptosis earlier in development. Consistent with this hypothesis, testicular atrophy is preceded by increased testicular weight and hypercellular tubules in immature Bax-deficient mice. TUNEL staining at Postnatal Day (P) 7 and morphological quantitation between P5 and P15 demonstrates decreased germ cell apoptosis in Bax-deficient mice. By P15, increased numbers of type A spermatogonia, and at P12 and P15, an increase in intermediate type spermatogonia were noted in Bax-deficient animals. By P25, the number of basal compartment cells was greatly increased in Bax-deficient animals compared with controls such that four or five layers of preleptotene spermatocytes were routinely present within the basal compartment of the testis. Although the Sertoli cell barrier was significantly r...Continue Reading

References

Mar 1, 1984·Journal of Reproduction and Fertility·L D Russell, R N Peterson
Oct 6, 1995·Science·C M KnudsonS J Korsmeyer
Oct 21, 1994·Cell·Z N Oltvai, S J Korsmeyer
Aug 1, 1997·Nature Genetics·C M Knudson, S J Korsmeyer
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Y HsuA J Hsueh
Sep 12, 1998·Science·J M Adams, S Cory
Aug 13, 1999·Genes & Development·A GrossS J Korsmeyer
Jun 17, 2000·Trends in Neurosciences·C Y KuanP Rakic
Jul 14, 2000·Molecular Endocrinology·E B RuckerL Hennighausen
Jan 6, 2001·Molecular Reproduction and Development·A L Kierszenbaum

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Citations

Sep 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Emily J ClementeNabeel A Affara
Nov 7, 2007·Pediatric Surgery International·Igor SukhotnikJorge G Mogilner
Mar 15, 2006·Apoptosis : an International Journal on Programmed Cell Death·L KonradR Hofmann
Jan 28, 2009·Apoptosis : an International Journal on Programmed Cell Death·Delphine Mérino, Philippe Bouillet
Nov 4, 2011·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Felipe F DiasRossana C N Melo
Jul 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yueh-Chiang HuDavid C Page
May 6, 2009·Human Reproduction Update·João Ramalho-SantosAlexandra Amaral
Oct 2, 2013·Human Reproduction Update·Alexandra AmaralRafael Oliva
Jan 21, 2012·Biology of Reproduction·Paulo Henrique A Campos-JuniorLuiz R de França
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chandrima ShahaDurga Prasad Mishra
Mar 3, 2005·Development, Growth & Differentiation·Tatsuo KidoSeiji Shioda
Mar 26, 2003·Cell Structure and Function·Kazuhiro Sakamaki
Sep 1, 2012·PloS One·Guilherme M J CostaLuiz R Franca
May 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Valeria MericoNori Tolosa de Talamoni
Jan 25, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Chuck R GreenfeldJodi A Flaws
Apr 28, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Ana Luiza DrumondHélio Chiarini-Garcia
Nov 20, 2009·Journal of Molecular Histology·Leon M McCluskyMaria S Bornman
May 17, 2014·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Amanda V AlbuquerqueHélio Chiarini-Garcia
Aug 20, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Chao-Hui GuQiang-Song Tong
Feb 18, 2016·Scientific Reports·Heran WangMing Zhou
Jan 16, 2016·International Journal of Molecular Sciences·Yaping LiuGang Li
Apr 13, 2010·Biochemical and Biophysical Research Communications·May Al-MaghrebiJehoram T Anim
Jan 23, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Hongle ZhaoBin Cai
Mar 17, 2009·Fertility and Sterility·Fabrizio AntonangeliClaudia Giampietri
Feb 13, 2009·Animal Reproduction Science·Hélio Chiarini-GarciaFernanda R L C Almeida
Jul 4, 2008·Gynécologie, obstétrique & fertilité·D HaouziS Hamamah
Aug 1, 2015·Journal of Reproductive Immunology·Mukesh K JaiswalKenneth D Beaman
Mar 24, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Martine Culty

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