PMID: 8943066Nov 26, 1996Paper

BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway

Proceedings of the National Academy of Sciences of the United States of America
T StrobelS A Cannistra

Abstract

To investigate the role of BAX in chemotherapy-induced apoptosis, we transfected the SW626 human ovarian cancer cell line, which lacks functional p53, with a cDNA encoding for murine BAX. Immunoblotting revealed that BAX transfectants expressed a mean of 10-fold increased levels of BAX compared with neo-transfected control clones, with similar levels of BCL-2 and BCL-xL. The cytotoxicity of paclitaxel, vincristine, and doxorubicin was significantly enhanced in BAX transfectants compared with control clones, whereas the cytotoxicity profile of carboplatin, etoposide, and hydroxyurea was unchanged. Increased paclitaxel-induced cytotoxicity of BAX clones was associated with enhanced apoptosis, as assessed by morphologic and flow cytometric criteria. These data suggest that sufficient levels of BAX may bypass the need for upstream molecules such as p53 in the process of chemotherapy-induced apoptosis.

References

Jan 1, 1992·Cytometry·Z DarzynkiewiczF Traganos
Oct 1, 1994·The Journal of Cell Biology·K Schulze-OsthoffP H Krammer
Sep 1, 1995·The Journal of Experimental Medicine·D T ChaoS J Korsmeyer
Apr 20, 1995·Nature·T ChittendenB C Guild
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·S HaldarC M Croce
Oct 21, 1994·Cell·Z N Oltvai, S J Korsmeyer
Nov 4, 1994·Science·S W LoweT Jacks
Nov 18, 1993·The New England Journal of Medicine·S A Cannistra
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jan 1, 1994·The Journal of Cell Biology·J C Reed
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J KupryjańczykD W Yandell

❮ Previous
Next ❯

Citations

Jun 12, 2012·Bioprocess and Biosystems Engineering·Soumya ChatterjeeKrishnendu Acharya
Sep 21, 2013·Apoptosis : an International Journal on Programmed Cell Death·Do Young KimKwang-Hyub Han
Apr 16, 1998·Pharmacology & Therapeutics·F ZuninoF Arcamone
Dec 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·D R GandaraP H Gumerlock
Jul 27, 1999·International Journal of Radiation Oncology, Biology, Physics·E RakovitchC R Geard
Jan 7, 2003·Hematology/oncology Clinics of North America·Anthony W Tolcher
Aug 11, 2001·Free Radical Biology & Medicine·G VarbiroB Sumegi
Dec 6, 1997·Current Opinion in Genetics & Development·J L Rinkenberger, S J Korsmeyer
May 12, 1998·Surgical Oncology·R J BoldD J McConkey
Nov 13, 2008·Cytotechnology·B ChauffertE Solary
Jul 24, 2008·Nature Clinical Practice. Oncology·Panagiotis A KonstantinopoulosStephen A Cannistra
Aug 16, 2002·Cell Death and Differentiation·S J HeiligtagK A David
Dec 14, 2004·The New England Journal of Medicine·Stephen A Cannistra
Mar 8, 2011·Journal of Gastroenterology and Hepatology·Xiao-Tong HeXi-Liang Zha
Jan 28, 2010·Cancer Research·Jason Doles, Michael T Hemann
Oct 7, 2004·Biological & Pharmaceutical Bulletin·Seong-Gyu KoMin-Kyu Shin
Feb 6, 2009·PLoS Medicine·Anne P G CrijnsAte G J van der Zee
Feb 4, 2011·OncoTargets and Therapy·Jonathan R Aspe, Nathan R Wall
Nov 12, 2009·Future Oncology·W Brian Dalton, Vincent W Yang
Sep 2, 1999·Journal of Neurosurgery·M A VogelbaumK M Rich
Oct 26, 2001·Biochemical and Biophysical Research Communications·S PalG Sa
May 15, 2008·Asian Journal of Andrology·Chun-Xiao YuJian-Ye Zhang
Apr 25, 2000·Biochemical and Biophysical Research Communications·E SchmittR Bertrand
Jan 9, 2014·In Vitro Cellular & Developmental Biology. Animal·Nikhil Baban GhateNripendranath Mandal
Mar 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y TsurutaS Fujii
Oct 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R SupinoF Zunino
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·P Scheipers, H Reiser
Sep 24, 2015·Medicinal Research Reviews·Zhiqing LiuJia Zhou
Jul 1, 1997·Expert Opinion on Investigational Drugs·D M Bollag
Aug 21, 2012·Cancer Treatment Reviews·Arun Kanakkanthara, John H Miller
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·P De FeudisM Broggini
Jul 25, 2009·Clinics in Liver Disease·Howard C MasuokaGregory J Gores
Oct 22, 2008·Gynecologic Oncology·Izabela Ziółkowska-SetaJolanta Kupryjańczyk
Jan 12, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kanako TakemuraHiroyoshi Hiratsuka

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis