Bax-independent inhibition of apoptosis by Bcl-XL

Nature
E H ChengJ M Hardwick

Abstract

The Bcl-2-related protein, Bcl-XL, has been shown to block apoptosis induced by a variety of stimuli and to be a stronger protector against apoptosis than Bcl-2 under certain circumstances. Using site-specific mutagenesis, we show here that the amino-acid residues critical for protection of cells by Bcl-XL against Sindbis virus-induced apoptosis are clustered within the Bcl-2-homology regions 1 and 2 (BH1 and BH2 regions). The residues necessary for Bcl-XL function are not identical to those required for Bcl-2 function. Although it has been suggested that heterodimerization between Bcl-XL and Bax is essential for the anti-death activity of Bcl-XL (refs 7,8), our results suggest that the interaction with Bax is not required for Bcl-XL to exert its death-repressing activity. Specific mutations that disrupt the ability of Bcl-XL to interact with Bax or Bak still preserve 70-80% of the anti-death activity of wild-type Bcl-XL.

References

Jul 1, 1988·Journal of Virology·S LustigJ H Strauss
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·A R GottschalkJ Quintáns
Oct 6, 1995·Science·C M KnudsonS J Korsmeyer
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W SedlakS J Korsmeyer
Jun 1, 1995·Geburtshilfe und Frauenheilkunde·L C Fuith, W Pflanzl
Apr 20, 1995·Nature·T ChittendenB C Guild
Apr 27, 1995·Nature·S ShimizuY Tsujimoto
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M González-GarcíaG Núñez
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·S UbolJ M Hardwick
Mar 1, 1996·Journal of Virology·J LewisJ M Hardwick

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Citations

Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·G G ReA J Garvin
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·U WüllnerT Klockgether
Mar 21, 2001·Biotechnology and Bioengineering·B FigueroaM J Betenbaugh
Feb 22, 2002·The Journal of Pathology·A SaxenaD J Thomson
Jun 1, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xiangzheng ChenJinliang Yang
Apr 22, 2005·Apoptosis : an International Journal on Programmed Cell Death·V S Goldmacher
Mar 21, 2006·Apoptosis : an International Journal on Programmed Cell Death·Y K VermaH G Raj
Sep 26, 2009·Apoptosis : an International Journal on Programmed Cell Death·Dana WestphalAndrew A Mercer
Nov 13, 2008·Cytotechnology·Nilou Arden, M J Betenbaugh
Apr 29, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhongqiu LuGuangliang Hong
May 15, 2004·Cancer Letters·G Radhakrishna PillaiEwa Carrier
Mar 25, 2004·Trends in Biotechnology·Nilou Arden, Michael J Betenbaugh
Aug 26, 1998·Biochimica Et Biophysica Acta·J CaiD P Jones
Jul 11, 1998·Fertility and Sterility·D M LeeJ Yeh
May 5, 2001·Pharmacology & Therapeutics·C R Weinstein-OppenheimerJ A McCubrey
Apr 16, 1998·Pharmacology & Therapeutics·F ZuninoF Arcamone
Apr 2, 1999·Trends in Pharmacological Sciences·R A KinlochI Hajimohamadreza
Oct 10, 2001·Biochimica Et Biophysica Acta·M ZörnigG Evan
Sep 16, 1999·Mutation Research·E Bossy-Wetzel, D R Green
Feb 1, 1997·Current Opinion in Genetics & Development·L Rao, E White
Nov 1, 1997·Trends in Cardiovascular Medicine·D S ParkL A Greene
Aug 5, 2011·Cell Death & Disease·X TengJ M Hardwick
Nov 10, 2011·Molecular Therapy : the Journal of the American Society of Gene Therapy·Pong-Yu HuangLih-Hwa Hwang
Dec 2, 2006·Nature Cell Biology·Heidi L Galonek, J Marie Hardwick
Aug 1, 1997·Nature Genetics·C M Knudson, S J Korsmeyer
Jan 19, 2008·Nature Reviews. Cancer·Anthony G Letai
Dec 18, 2007·Cell Death and Differentiation·A M Flanagan, A Letai
Nov 4, 2000·The Biochemical Journal·T R HuppK L Ball
Apr 29, 1998·Immunology and Cell Biology·L F Lincz
Nov 15, 2000·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·J KimG L Ellis
Nov 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jamie I FletcherJerry M Adams

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