Bay or baylike regions of polycyclic aromatic hydrocarbons were potent inhibitors of Gap junctional intercellular communication

Environmental Health Perspectives
Liliane M WeisBrad L Upham

Abstract

Many polycyclic aromatic hydrocarbons (PAHs) are known carcinogens, and a considerable amount of research has been devoted to predicting the tumor-initiating potential of PAHs based on chemical structure. However, there has been little research into the effects of PAHs on the epigenetic events of tumor promotion and no structural correlation has been made thereof. Gap junctional intercellular communication (GJIC) activity was used in this study as an epigenetic biomarker to determine the structure-activity relationships of twelve different PAHs. The PAHs used were naphthalene, 1-methylnaphthalene, 2-methylnaphthalene, anthracene, 1-methylanthracene, 2-methylanthracene, 9-methylanthracene, 9, 10-dimethylanthracene, phenanthrene, fluorene, 1-methylfluorene, and fluoranthene. Results showed that PAHs containing bay or baylike regions inhibited GJIC more than did the linear PAHs. The nonnaphthalene PAHs were not cytotoxic as determined by a vital dye uptake assay, but the naphthalene compounds were cytotoxic at the higher doses, indicating that the down regulation of GJIC by these naphthalenes could be a consequence of general membrane damage. Inhibition of GJIC by all the inhibitory PAHs was reversed when the cells were refreshed ...Continue Reading

References

Jun 1, 1976·Journal of the National Cancer Institute·B L Van Duuren, B M Goldschmidt
Jan 1, 1976·Annals of the New York Academy of Sciences·C K RedmondR H Cypess
Jan 1, 1991·Teratogenesis, Carcinogenesis, and Mutagenesis·J W Flesher, S R Myers
Jan 1, 1990·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·J E TroskoJ E Klaunig
Jan 1, 1990·Pharmacology & Therapeutics·J A Boyd, J C Barrett
Dec 1, 1987·Mutation Research·R Holliday
Mar 30, 1988·Biochemical and Biophysical Research Communications·S R MyersJ W Flesher
Feb 1, 1985·Toxicology Letters·E Borenfreund, J A Puerner
Jan 1, 1983·Cancer Investigation·J E TroskoA Medcalf
Oct 1, 1994·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B L UphamJ E Trosko
Jun 1, 1994·Risk Analysis : an Official Publication of the Society for Risk Analysis·J E TroskoB V Madhukar
Jun 1, 1996·Carcinogenesis·H Yamasaki, C C Naus
Jan 1, 1996·Free Radical Biology & Medicine·P J VuchetichS J Stohs
Sep 1, 1996·Mutagenesis·K J StockerR J Proudlock
Dec 1, 1996·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·B L UphamJ E Trosko
Sep 1, 1962·British Journal of Cancer·F J ROE
Jan 1, 1964·Progress in Experimental Tumor Research·R K BOUTWELL
Aug 1, 1964·Archives of Environmental Health·H L FALKS THOMPSON
Jan 1, 1990·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J E TroskoB V Madhukar

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Citations

Jul 19, 2013·BioMed Research International·Abderrahim NemmarErnesto Alfaro-Moreno
Jun 13, 2002·Environmental Health Perspectives·Carl-Elis BoströmRoger Westerholm
Mar 31, 2004·Toxicology and Applied Pharmacology·Katerina ChramostováMiroslav Machala
Oct 1, 2005·Journal of Advanced Nursing·George RichardsonRaymond Jones
Aug 28, 2016·Environmental Science and Pollution Research International·Pardeep SinghPradeep Kumar Mishra
Jul 10, 2003·Journal of Toxicology and Environmental Health. Part a·Leslie CizmasKirby C Donnelly
Jan 18, 2003·International Journal of Cancer. Journal International Du Cancer·Brad L UphamNorbert E Kaminski
Apr 13, 2001·Molecular Carcinogenesis·J E Trosko
Feb 3, 2007·International Journal of Cancer. Journal International Du Cancer·Mei-Hui TaiJames E Trosko
Oct 28, 2009·Carcinogenesis·Philippe Irigaray, Dominique Belpomme
Jul 29, 2009·Critical Reviews in Biochemistry and Molecular Biology·Mathieu VinkenVera Rogiers
Jun 7, 2019·Environmental Science and Pollution Research International·Arti MishraIndu Shekhar Thakur
Jun 3, 2017·Environmental Management·Oluwadara Oluwaseun AlegbeleyeVanessa Angela Jackson
Nov 17, 2001·Toxicon : Official Journal of the International Society on Toxinology·Anelia HorvathJames E Trosko
Aug 28, 2021·International Journal of Molecular Sciences·Iva SovadinováPavel Babica

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