Bayesian analysis of structural equation models with multinomial variables and an application to type 2 diabetic nephropathy

Statistics in Medicine
Xin-Yuan SongJuliana C N Chan

Abstract

There is now increasing evidence proving that many complex diseases can be significantly influenced by correlated phenotype and genotype variables, as well as their interactions. Effective and rigorous assessment of such influence is difficult, because the number of phenotype and genotype variables of interest may not be small, and a genotype variable is an unordered categorical variable that follows a multinomial distribution. To address the problem, we establish a novel nonlinear structural equation model for analysing mixed continuous and multinomial data that can be missing at random. A confirmatory factor analysis model with Kronecker product is proposed for grouping the manifest continuous and multinomial variables into latent variables according to their functions; and a nonlinear structural equation is formulated to assess the linear and interaction effects of the independent latent variables to the dependent latent variables. Bayesian methods for estimation and model comparison are developed through Markov chain Monte Carlo techniques and path sampling. The newly developed methodologies are applied to a case-control cohort of type 2 diabetic patients with nephropathy.

References

Jan 1, 1992·Statistical Methods in Medical Research·P M Bentler, J A Stein
Dec 1, 1996·Journal of the American Society of Nephrology : JASN·H H ParvingP Rossing
Jul 9, 1998·The New England Journal of Medicine·P FiorettoM Mauer
Oct 16, 1999·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·M PowerM Bullinger
Mar 17, 2001·Biometrics·F Dominici, G Parmigiani
Jan 10, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·P J AndersonB Tomlinson
Dec 25, 2002·Bioinformatics·Kyeong Eun LeeBani K Mallick
Aug 21, 2003·Biometrics·David B DunsonJack A Taylor
Sep 16, 2003·Statistics in Medicine·Sik-Yum Lee, Xin-Yuan Song
Jun 18, 2004·Bioinformatics·Mark Girolami, Rainer Breitling
Jun 1, 1984·IEEE Transactions on Pattern Analysis and Machine Intelligence·S Geman, D Geman

❮ Previous
Next ❯

Citations

Oct 5, 2013·Psychometrika·Xin-Yuan SongEdward Hak-Sing Ip
Jul 2, 2008·The British Journal of Mathematical and Statistical Psychology·Sik-Yum LeeChung-Ngor Juliana Chan
Nov 17, 2007·Statistics in Medicine·Sik-Yum LeeXin-Yuan Song
Aug 19, 2010·Genetic Epidemiology·B A S Nonyane, J C Whittaker
Dec 18, 2013·Statistics in Medicine·Xinyuan SongXiangnan Feng
Feb 19, 2014·Statistical Methods in Medical Research·Xin-Yuan SongJing-Heng Cai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.