Apr 5, 2020

Genetic diversity of Anopheles coustani in high malaria transmission foci in southern and central Africa

BioRxiv : the Preprint Server for Biology
Ilinca I. CiubotariuD. E. Norris

Abstract

Despite ongoing malaria control efforts implemented throughout sub-Saharan Africa, malaria remains an enormous public health concern. Current interventions such as indoor residual spraying with insecticides and use of insecticide-treated bed nets are aimed at targeting the key malaria vectors that are primarily endophagic and endophilic. While these control measures have resulted in a substantial decline in malaria cases and continue to impact indoor transmission, the importance of alternative vectors for malaria transmission has been largely neglected. Anopheles coustani, an understudied vector of malaria, is a species previously thought to exhibit mostly zoophilic behavior. However, recent studies from across Africa bring to light the contribution of this and ecologically similar anopheline species to human malaria transmission. Like many of these understudied species, An. coustani has greater anthropophilic tendencies than previously appreciated, is often both endophagic and exophagic, and carries Plasmodium falciparum sporozoites. These recent developments highlight the need for more studies throughout the geographic range of this species and the potential need to control this vector. The aim of this study was to explore th...Continue Reading

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Mentioned in this Paper

Fertility
Genome
Infertility Study
Dysequilibrium Syndrome
Mathematical Formula
Hermaphroditism
Locus
Markov Chain Monte Carlo Methodology
Alleles
Inbreeding

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