Bayesian determination of the effect of a deep eutectic solvent on the structure of lipid monolayers

Physical Chemistry Chemical Physics : PCCP
Andrew R McCluskeyT Arnold

Abstract

In this work, we present the first example of the self-assembly of phospholipid monolayers at the interface between air and an ionic solvent. Deep eutectic solvents are a novel class of environmentally friendly, non-aqueous, room temperature liquids with tunable properties, that have wide-ranging potential applications and are capable of promoting the self-assembly of surfactant molecules. We use a chemically-consistent Bayesian modelling of X-ray and neutron reflectometry measurements to show that these monolayers broadly behave as they do on water. This method allows for the monolayer structure to be determined, alongside the molecular volumes of the individual monolayer components, without the need for water-specific constraints to be introduced. Furthermore, using this method we are able to better understand the correlations present between parameters in the analytical model. This example of a non-aqueous phospholipid monolayer has important implications for the potential uses of these solvents and for our understanding of how biomolecules behave in the absence of water.

References

Jan 1, 1990·Annual Review of Physical Chemistry·H Möhwald
May 1, 1994·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·W SunJ F Nagle
Nov 16, 2002·Science·H KraackM Deutsch
May 13, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·María C GutiérrezFrancisco del Monte
Jul 6, 2010·Chemistry and Physics of Lipids·Derek Marsh
Apr 20, 2012·Journal of Synchrotron Radiation·Thomas ArnoldMartin Burt
Feb 23, 2013·Analytica Chimica Acta·Yuntao DaiYoung Hae Choi
Dec 7, 2013·Physical Chemistry Chemical Physics : PCCP·Ashish PandeySiddharth Pandey
Oct 11, 2014·Chemical Reviews·Emma L SmithKarl S Ryder
Nov 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Thomas ArnoldKaren J Edler
Dec 25, 2015·Soft Matter·Saffron J BryantGregory G Warr
Mar 11, 2016·The Journal of Physical Chemistry. a·Liel SapirDaniel Harries
Aug 24, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Stefan ZahnDoreen Mollenhauer
Nov 30, 2016·Physical Chemistry Chemical Physics : PCCP·Adrian Sanchez-FernandezKaren J Edler
Mar 17, 2017·Physical Chemistry Chemical Physics : PCCP·A Sanchez-FernandezA J Jackson
Jun 20, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Saffron J BryantGregory G Warr
Jul 13, 2017·The Journal of Physical Chemistry. B·Oliver S HammondKaren J Edler
Aug 22, 2017·Advances in Colloid and Interface Science·Larissa BraunRichard A Campbell
May 11, 2018·Physical Chemistry Chemical Physics : PCCP·A Sanchez-FernandezA J Jackson
Jul 22, 2018·Journal of Colloid and Interface Science·Richard A CampbellM Jayne Lawrence
Aug 8, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Yi-Ting Hsieh, Yan-Ru Liu
Feb 26, 2019·Journal of Applied Crystallography·Andrew R J Nelson, Stuart W Prescott

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
neutron reflectometry

Software Mentioned

Python
emcee
MOTOFIT
GenX
Aurore
scipy
Jupyter
Refl1D
refnx
Rascal

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.