Bayesian Hierarchical Joint Modeling Using Skew-Normal/Independent Distributions

Communications in Statistics: Simulation and Computation
Geng Chen, Sheng Luo

Abstract

The multiple longitudinal outcomes collected in many clinical trials are often analyzed by multilevel item response theory (MLIRT) models. The normality assumption for the continuous outcomes in the MLIRT models can be violated due to skewness and/or outliers. Moreover, patients' follow-up may be stopped by some terminal events (e.g., death or dropout) which are dependent on the multiple longitudinal outcomes. We proposed a joint modeling framework based on the MLIRT model to account for three data features: skewness, outliers, and dependent censoring. Our method development was motivated by a clinical study for Parkinson's disease.

References

Sep 1, 1978·Bulletin of Environmental Contamination and Toxicology·D Werner, H Pawlitz

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Citations

Apr 28, 2020·BMC Medical Research Methodology·Maha AlsefriRuwanthi Kolamunnage-Dona

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