Apr 25, 2020

Identification and characterization of the hypoxia response regulatory elements in the accessible genome

BioRxiv : the Preprint Server for Biology
Xingqi Chen, x. lu

Abstract

Hypoxia is commonly observed in the solid tumor and contributes to the drug resistance in cancer therapy. Deciphering the epigenetic feature under the hypoxia condition in the solid tumor is critical for us to understand the tumorigenesis and design the precision therapy. Using the time series of ATAC-seq data under the hypoxia treatment from the epithelia cells, we identified the hypoxia response regulatory elements (HRREs) in the accessible genome. We found that these different HRREs have unique genomic features and are enriched with different transcriptional factors (TFs). Our study provides insights into the chromatin structure response to the hypoxia treatment and identifies useful genomic features for a better understanding of the hypoxia biology in the solid tumor.

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Mentioned in this Paper

Pathogenic Organism
Recombination, Genetic
Phylogenetic Analysis
Homologous Recombination
Isolate - Microorganism
Escherichia coli O157
Rural Area
Biological Evolution
Homologous Recombination Pathway

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