Bayesian Inference Reveals Host-Specific Contributions to the Epidemic Expansion of Influenza A H5N1

Molecular Biology and Evolution
Nídia Sequeira TrovãoPhilippe Lemey

Abstract

Since its first isolation in 1996 in Guangdong, China, the highly pathogenic avian influenza virus (HPAIV) H5N1 has circulated in avian hosts for almost two decades and spread to more than 60 countries worldwide. The role of different avian hosts and the domestic-wild bird interface has been critical in shaping the complex HPAIV H5N1 disease ecology, but remains difficult to ascertain. To shed light on the large-scale H5N1 transmission patterns and disentangle the contributions of different avian hosts on the tempo and mode of HPAIV H5N1 dispersal, we apply Bayesian evolutionary inference techniques to comprehensive sets of hemagglutinin and neuraminidase gene sequences sampled between 1996 and 2011 throughout Asia and Russia. Our analyses demonstrate that the large-scale H5N1 transmission dynamics are structured according to different avian flyways, and that the incursion of the Central Asian flyway specifically was driven by Anatidae hosts coinciding with rapid rate of spread and an epidemic wavefront acceleration. This also resulted in long-distance dispersal that is likely to be explained by wild bird migration. We identify a significant degree of asymmetry in the large-scale transmission dynamics between Anatidae and Phasi...Continue Reading

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Citations

Mar 8, 2016·Current Opinion in Virology·Yong-Zhen Zhang, Jianguo Xu
Oct 25, 2016·Virus Evolution·Nídia Sequeira TrovãoPhilippe Lemey
Jun 24, 2016·Bioinformatics·Simon DellicourOliver G Pybus
Aug 16, 2019·Journal of Virology·Deborah U EhichioyaStephan Günther
Nov 24, 2019·Nature Communications·Alice FusaroIsabella Monne
Dec 7, 2018·PLoS Pathogens·Huaiyu TianSimon Dellicour
Oct 7, 2017·BMC Medical Genomics·Niu QiaoLei Liu
Nov 6, 2018·Microbiology Spectrum·Ricardo Parreira
Sep 30, 2021·Microbiology Spectrum·Yao-Tsun LiGavin J D Smith

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