Bayesian latent time joint mixed effect models for multicohort longitudinal data

Statistical Methods in Medical Research
Dan LiAlzheimer’s Disease Neuroimaging Initiative

Abstract

Characterization of long-term disease dynamics, from disease-free to end-stage, is integral to understanding the course of neurodegenerative diseases such as Parkinson's and Alzheimer's, and ultimately, how best to intervene. Natural history studies typically recruit multiple cohorts at different stages of disease and follow them longitudinally for a relatively short period of time. We propose a latent time joint mixed effects model to characterize long-term disease dynamics using this short-term data. Markov chain Monte Carlo methods are proposed for estimation, model selection, and inference. We apply the model to detailed simulation studies and data from the Alzheimer's Disease Neuroimaging Initiative.

References

Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
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Citations

Jun 28, 2019·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Arthur R Gilmour
Dec 4, 2019·ELife·Sara GarbarinoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 13, 2019·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Murat Bilgel, Bruno M Jedynak
Jun 15, 2020·Alzheimer's Research & Therapy·Christoforos HadjichrysanthouUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 30, 2019·Brain Informatics·Samuel IddiUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 20, 2020·NeuroImage·Mostafa Mehdipour GhaziLauge Sørensen
Feb 6, 2021·Brain : a Journal of Neurology·Neil P OxtobyRimona S Weil
Jan 30, 2020·Computer Methods and Programs in Biomedicine·Gerard Martí-JuanGemma Piella
Apr 15, 2021·Statistics in Medicine·Line KühnelLars L Raket
Jun 5, 2021·Brain Communications·Clément Abi NaderUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 17, 2021·Brain Communications·Julie UchitelMohamad A Mikati
Sep 29, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Line KühnelUNKNOWN MEMENTO study group and the Alzheimer's Disease Neuroimaging Initiative

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Software Mentioned

LTJMM
R
R package rstan ( Stan Development Team
Stan
R package

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