Bayesian mapping of multiple quantitative trait loci from incomplete inbred line cross data.

Genetics
Mikko J Sillanpää, Elja Arjas

Abstract

A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosomes. The method is introduced for inbred lines and it can be applied also in situations involving frequent missing genotypes. We propose that two new probabilistic measures be used to summarize the results from the statistical analysis: (1) the (posterior) QTL intensity, for estimating the number of QTLs in a chromosome and for localizing them into some particular chromosomal regions, and (2) the locationwise (posterior) distributions of the phenotypic effects of the QTLs. Both these measures will be viewed as functions of the putative QTL locus, over the marker range in the linkage group. The method is tested and compared with standard interval and composite interval mapping techniques by using simulated backcross progeny data. It is implemented as a software package. Its initial version is freely available for research purposes under the name Multimapper at URL http://www.rni.helsinki.fi/mjs.

References

Jan 1, 1992·Human Heredity·D C Thomas, V Cortessis
Mar 1, 1995·Genetics·L Kruglyak, E S Lander
Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Apr 1, 1994·Genetics·Z B Zeng
Jan 1, 1993·Annual Review of Genetics·S D Tanksley
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Z B Zeng
Jan 1, 1993·Annals of Human Genetics·D A Stephens, A F Smith
Jun 1, 1996·Genetics·P M VisscherC S Haley
Jun 1, 1984·IEEE Transactions on Pattern Analysis and Machine Intelligence·S Geman, D Geman

❮ Previous
Next ❯

Citations

Oct 19, 2006·Yi chuan xue bao = Acta genetica Sinica·Yuan-Ming Zhang
Apr 19, 2005·Genetics·Cynthia J CoffmanLauren M McIntyre
Jul 2, 1999·Genetics·C H KaoR D Teasdale
Jul 24, 2008·Heredity·M J Sillanpää, N Noykova
Aug 19, 2004·Molecular Ecology·David L EricksonDonald Price
Oct 27, 2007·BMC Bioinformatics·Dario GasbarraElja Arjas
Jun 2, 2005·Animal Biotechnology·Christiane HansenHans H Cheng
Apr 6, 2006·Genetics·Jian LiZhao-Bang Zeng
Sep 17, 2004·Genetics·Mikko J Sillanpää, Madhuchhanda Bhattacharjee
Jul 11, 2001·Theoretical Population Biology·B Walsh
Oct 10, 2002·Annals of Medicine·Mikko J Sillanpää
Mar 16, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Hiroyoshi IwataTakeshi Hayashi
May 24, 2003·Heredity·L Luo, S Xu
Aug 26, 1999·Trends in Genetics : TIG·J S ShoemakerB S Weir
Apr 17, 2007·Genetics·Runqing Yang, Shizhong Xu
Aug 10, 2001·Trends in Plant Science·J JanninkR C Jansen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.