PMID: 9523800Apr 2, 1998Paper

Bayesian modeling of muscle biopsy contracture testing for malignant hyperthermia susceptibility

Anesthesiology
Julian Loke, D H MacLennan

Abstract

Phenotyping malignant hyperthermia (MH) by contracture testing has a low but quantifiable degree of inaccuracy, measured by its sensitivity and specificity. Quantifying the limitations inherent in diagnostic testing for MH can help resolve issues in clinical practice, such as the interpretation of a negative test and the apparent lack of complete genetic linkage to RYR1. Bayesian models, mathematical descriptions of the outcome of diagnostic testing, were constructed. The inputs to the model include patient factors, summarized in a single number called pretest probability (PTP), and sensitivity and specificity that specify the accuracy of the entire test process. The outputs of the model include positive predictive value (PPV) and negative predictive value (NPV), which are numeric expressions of diagnostic certainty of positive and negative test results. A special case was constructed for equivocal results. The PPV, NPV, and efficiency of contracture testing for MH are functions of PTP, sensitivity, and specificity. The NPV is high for all clinical PTP, whereas PPV is clinically useful for moderate to high PTP. Diagnostic contracture testing for MH is clinically useful because of high NPV and can exclude MH with near certainty....Continue Reading

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Citations

Oct 19, 2013·Annales Françaises D'anesthèsie Et De Rèanimation·M Le GuenO Langeron
Jul 21, 2009·Anesthesia and Analgesia·John F Capacchione, Sheila M Muldoon
Dec 17, 2008·Srpski arhiv za celokupno lekarstvo
Sep 24, 2005·Journal of the American Veterinary Medical Association·Patricia K DranchakJames R Mickelson
Oct 3, 2006·Current Opinion in Anaesthesiology·P J Adnet, G A Gronert
Dec 26, 2001·Anesthesiology·Henry RosenbergSheila Muldoon
Oct 27, 2005·Anesthesiology·Barbara W Brandom, Sheila M Muldoon
Jan 20, 2005·The Biochemical Journal·Kalanethee Paul-PletzerJerome Parness
Sep 6, 2000·Arquivos de neuro-psiquiatria·H C SilvaA M Tsanaclis
May 18, 2021·Frontiers in Pharmacology·Emanuele MicaglioCarlo Pappone
Dec 2, 2010·Biochimica Et Biophysica Acta·David H Maclennan, Elena Zvaritch

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