Abstract
In the course of hypertension, cardiovascular disease events (e.g., stroke, heart failure) occur frequently and recurrently. The scientific interest in such study may lie in the estimation of treatment effect while accounting for the correlation among event times. The correlation among recurrent event times come from two sources: subject-specific heterogeneity (e.g., varied lifestyles, genetic variations, and other unmeasurable effects) and event dependence (i.e., event incidences may change the risk of future recurrent events). Moreover, event incidences may change the disease progression so that there may exist event-varying covariate effects (the covariate effects may change after each event) and event effect (the effect of prior events on the future events). In this article, we propose a Bayesian regression model that not only accommodates correlation among recurrent events from both sources, but also explicitly characterizes the event-varying covariate effects and event effect. This model is especially useful in quantifying how the incidences of events change the effects of covariates and risk of future events. We compare the proposed model with several commonly used recurrent event models and apply our model to the motiva...Continue Reading
References
Aug 1, 1991·Statistics in Medicine·O O Aalen, E Husebye
May 1, 1982·Stroke; a Journal of Cerebral Circulation·R L SaccoP M McNamara
Apr 1, 1996·American Journal of Hypertension·B R DavisC M Hawkins
Jan 1, 1995·Lifetime Data Analysis·P Hougaard
Jan 7, 2000·Statistics in Medicine·P J Kelly, L L Lim
Jul 24, 2002·Circulation·Barbara V Howard, Judith Wylie-Rosett
Sep 17, 2002·Biometrics·Xuelin Huang, Robert A Wolfe
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Dec 2, 2005·Statistics in Medicine·Juan R GonzálezElizabeth H Slate
Dec 14, 2005·Statistics in Medicine·Janet M Box-Steffensmeier, Suzanna De Boef
Aug 11, 2007·Biometrics·Xuelin Huang, Lei Liu
Oct 27, 2009·Statistics in Medicine·Allan B Clark, Max O Bachmann
Jul 14, 2010·Lifetime Data Analysis·Håkon K GjessingOdd O Aalen
Jan 26, 2011·Circulation·Paul A HeidenreichUNKNOWN Council on Cardiovascular Surgery and Anesthesia, and Interdisciplinary Council on Quality of Care and Outcomes Research
Mar 26, 2014·Nature Reviews. Cardiology·Nathan D Wong