BbrPI, an extracellular proteinase inhibitor of Bacillus brevis, protects cells from the attack of exogenous proteinase

Bioscience, Biotechnology, and Biochemistry
Y ShigaS Udaka

Abstract

BbrPI, an extracellular serine proteinase inhibitors of B. brevis HPD31, is activated by proteolytic processing of an inactive precursor. To discover the physiological role of BbrPI, its deficient mutants were genetically constructed. Although the BbrPI deficient mutant had a higher extracellular proteinase activity than the parent strain, it grew normally. The BbrPI deficient mutant showed higher sensitivity to added trypsin than that of the parent. These observations suggest that the BbrPI may play a role in cellular protection from the attack of exogenous proteinases.

Citations

Mar 30, 2010·Applied and Environmental Microbiology·Francesca TurroniMarco Ventura
Mar 19, 2014·Journal of Microbiological Methods·David Quintero, David Bermudes
Sep 26, 2001·Protein Expression and Purification·K YashiroR J Moore
Jun 27, 2006·Molecular Microbiology·Wolfgang H Schwarz, Vladimir V Zverlov
Jan 26, 2011·Prikladnaia biokhimiia i mikrobiologiia·E V Lavrent'evaB B Namsaraev
Apr 22, 2006·The Journal of Biological Chemistry·Dmitri IvanovFabrizio Arigoni
Jul 13, 2019·Frontiers in Immunology·Karina A PasquevichJuliana Cassataro

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