BC1 RNA protein particles in mouse brain contain two y-,h-element-binding proteins, translin and a 37 kDa protein

Biochemical and Biophysical Research Communications
T MuramatsuK Anzai

Abstract

Neural BC1 RNA is distributed in dendrites in the form of ribonucleoprotein particles (RNP). Recently, Han et al. reported that testis-brain RNA-binding protein (the mouse homologue of Translin), known to be a translational repressor, links a subset of mRNAs to microtubules (MTs) through binding to their y-,h-sequence elements. We found that similar elements are also present in BC1 RNA. Therefore, it is possible that they also act as cis-elements, together with their transacting proteins, and control the transport of BC1 RNA along dendritic MTs. In this study, we demonstrated that two y-,h-element-binding proteins copurified with BC1 RNP. One was identified as mouse Translin and the other was a 37 kDa protein. This macromolecular assembly may constitute a transport particle for BC1 RNA. It is also possible that BC1 RNP or Translin itself may play a regulatory role(s) in the translation of mRNAs within dendrites.

References

Mar 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·H TiedgeJ Brosius
Sep 1, 1986·Journal of Neurochemistry·K AnzaiS Goto
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T M DeChiara, J Brosius
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J G SutcliffeR A Lerner
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·J R HanN B Hecht
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·K MiyashiroJ Eberwine
Jul 1, 1996·DNA and Cell Biology·J G ChengJ Brosius
Apr 25, 1997·The Journal of Biological Chemistry·M KasaiK Suzuki
May 27, 1997·Proceedings of the National Academy of Sciences of the United States of America·X Q WuN B Hecht

❮ Previous
Next ❯

Citations

Oct 4, 2007·Molecular Psychiatry·J E ChubbJ K Millar
Oct 20, 1998·DNA and Cell Biology·J KremerskothenJ Brosius
Oct 10, 2006·Genetics·Maike ClaussenBeat Suter
Mar 24, 1999·The Journal of Cell Biology·C HerrmannW Volknandt
Apr 22, 2008·Biochimica Et Biophysica Acta·Zhi LiJay M Baraban
Jul 17, 2009·American Journal of Medical Genetics. Part a·Jaime M WilliamsDaryl A Scott
Jun 29, 2010·The Biochemical Journal·Alessa Jaendling, Ramsay J McFarlane
Sep 20, 2001·Journal of Structural Biology·M S VanLoockE H Egelman
Oct 3, 2002·Journal of Neurochemistry·Patricia M FinkenstadtJay M Baraban
Aug 31, 2000·Journal of Molecular Biology·A M RoyP L Deininger
Aug 7, 2002·FEBS Letters·Reiko IshidaMasataka Kasai
Sep 15, 2000·Journal of Neurochemistry·P M FinkenstadtJ M Baraban
Oct 12, 2000·Biochemical and Biophysical Research Communications·A CastroJ C Labbé
Aug 7, 2002·Journal of Molecular Biology·Neva WestPrescott Deininger
Aug 7, 2002·Journal of Molecular Biology·Ravi MuddashettyJürgen Brosius
Sep 7, 2007·Progress in Neurobiology·Bertil B FredholmMichail Sitkovsky

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.