BC3EE2,9B, a synthetic carbazole derivative, upregulates autophagy and synergistically sensitizes human GBM8901 glioblastoma cells to temozolomide

International Journal of Molecular Medicine
Chien-Min ChenChih-Li Lin

Abstract

Glioblastoma multiforme (GBM) is the most fatal form of human brain cancer. Although temozolomide (TMZ), an oral alkylating chemotherapeutic agent, improves the survival rate, the prognosis of patients with GBM remains poor. Naturally occurring carbazole alkaloids isolated from curry leaves (Murraya koenigii Spreng.) have been shown to possess a wide range of anticancer properties. However, the effects of carbazole derivatives on glioblastoma cells remain poorly understood. In the present study, anti‑glioblastoma profiles of a series of synthetic carbazole derivatives were evaluated in vitro. The most promising derivative in this series was BC3EE2,9B, which showed significant anti‑proliferative effects in GBM8401 and GBM8901 cells. BC3EE2,9B also triggered cell‑cycle arrest, most prominently at the G1 stage, and suppressed glioblastoma cell invasion and migration. Furthermore, BC3EE2,9B induced autophagy‑mediated cell death and synergistically sensitized GBM cells to TMZ cytotoxicity. The possible mechanism underlying BC3EE2,9B‑induced autophagy may involve activation of adenosine monophosphate-activated protein kinase and the attenuation of the Akt and mammalian target of the rapamycin downstream signaling pathway. Taken toget...Continue Reading

References

Jan 10, 2004·Cell Death and Differentiation·T KanzawaS Kondo
Apr 13, 2004·Oncogene·Devrim Gozuacik, Adi Kimchi
Oct 12, 2004·Cancer·Kenneth R HessMelissa L Bondy
Nov 9, 2004·Current Opinion in Cell Biology·Aimee L Edinger, Craig B Thompson
Apr 15, 2006·The Journal of Investigative Dermatology·Jack L ArbiserDale G Nagle
Jul 6, 2007·Autophagy·Noboru Mizushima, Tamotsu Yoshimori
Nov 2, 2007·Nature Reviews. Cancer·Robin MathewEileen White
Jan 27, 2009·Biochimica Et Biophysica Acta·Ning Chen, Vassiliki Karantza-Wadsworth
Feb 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alba A BrandesMario Ermani
Jun 27, 2009·Expert Opinion on Investigational Drugs·Cory AdamsonDarell D Bigner
Sep 25, 2010·European Journal of Medicinal Chemistry·Youssef HajbiAmélie Lansiaux
Dec 15, 2010·Autophagy·Han-Ming Shen, Patrice Codogno
Feb 22, 2012·Anti-cancer Agents in Medicinal Chemistry·David E ZembowerZe-Qi Xu
Jul 31, 2012·The Journal of Nutritional Biochemistry·Cristina P R XavierCristina Pereira-Wilson
Oct 18, 2012·Annual Review of Pathology·Lyndsay Murrow, Jayanta Debnath
Aug 24, 2013·Integrative Biology : Quantitative Biosciences From Nano to Macro·Chi-Chih KangLily Jun-shen Huang
Nov 7, 2013·JAMA : the Journal of the American Medical Association·Antonio Omuro, Lisa M DeAngelis
Aug 12, 2014·Current Medicinal Chemistry·Chen ChenKong-Nan Zhao

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
transfection

Software Mentioned

WinMDI
SPSS

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms