BCG scar and tuberculin reactivity in children and adults

Scandinavian Journal of Infectious Diseases
H FjällbrantLars Olof Larsson

Abstract

Bacille Calmette-Guérin (BCG) vaccination generally leads to scar formation and tuberculin skin test (TST) reactivity. This study aimed at analysing these 2 parameters and their correlation in a setting with a low prevalence of tuberculosis. Retrospectively, we analysed 314 children and 390 adults living in Sweden and known from records or individual recall to have undergone BCG vaccination. A BCG scar was present in 161 (51%) of the children and in 340 (87%) of the adults. Among children with a scar, 94 (58%) were TST-positive (>or=6 mm) compared to 23 (15%) of 154 children lacking a visible scar. Among adults with a scar, 258 (76%) were TST- positive compared to 23 (46%) of 50 with no scar. Out of 152 non-vaccinated adults, 142 (94.4%) were TST-negative. When 175 TST-negative health care students were BCG-vaccinated in a prospective part of the study, 174 (99%) were found to develop a scar. In essence, the study showed a positive correlation between scar presence and TST reactivity. Furthermore, BCG vaccination of adults in the present setting resulted in consistent scar formation, while scar prevalence in previously vaccinated children was low.

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Citations

Apr 9, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·R Piñeiro PérezM J Mellado Peña
Feb 25, 2009·Tropical Medicine & International Health : TM & IH·Fiona E KritzingerNulda Beyers
Dec 1, 2012·International Journal of Mycobacteriology·Zahra HasanNisar A Rao
Aug 9, 2012·Annals of Saudi Medicine·Manal A Murad, Samia S Abdulmageed
Jul 4, 2012·European Journal of Pediatrics·Roi PiñeiroMilagros García-Hortelano
May 15, 2012·Indian Journal of Pediatrics·Roi PiñeiroMaría José Mellado
Dec 26, 2012·Pathogens and Global Health·Roi Piñeiro-PérezMaría José Cilleruelo
Jan 30, 2020·Human Vaccines & Immunotherapeutics·Marco Antonio Yamazaki-NakashimadaRicardo U Sorensen
Oct 8, 2020·PloS One·Reka SzigetiRichard Kellermayer
Mar 22, 2021·Vaccine·Reka Szigeti, Richard Kellermayer
Jun 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Birger TrollforsAnna Dahlgren-Aronsson

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