PMID: 700898Oct 15, 1978Paper

BCG treatment of transplanted rat tumours of spontaneous origin

International Journal of Cancer. Journal International Du Cancer
M V PimmR W Baldwin

Abstract

Six transplanted rat tumours (three mammary carcinomas and three fibrosarcomas), all of spontaneous origin and of limited immunogenicity, have been examined for susceptibility to immunotherapy with BCG (Glaxo). Growth of limited numbers of cells from five tumours was suppressed when cells were injected subcutaneously in admixture with BCG organisms. There was no clear correlation between the immunogenicity of tumour lines and their susceptibility to regionally applied BCG. Active specific immunotherapy, using vaccines of viable or radiation-attenuated tumour cells in admixture with BCG, was reproducibly successful with only one tumour, the mammary carcinoma Sp4, this being the most immunogenic of the tumours examined. These studies indicate that naturally arising tumours are less susceptible to BCG-mediated suppression than carcinogen-induced tumours widely used for experimental immunotherapy, but indicate that local application of BCG may give the best therapeutic response.

References

Jan 15, 1978·International Journal of Cancer. Journal International Du Cancer·N KuzumakiG Klein
Mar 6, 1975·Nature·M V Pimm, R W Baldwin
Jan 1, 1977·Annual Review of Medicine·E M HershG M Mavligit
Dec 15, 1977·International Journal of Cancer. Journal International Du Cancer·M V Pimm, R W Baldwin
Jan 1, 1976·Annals of the New York Academy of Sciences·R W BaldwinM V Pimm
Oct 15, 1975·International Journal of Cancer. Journal International Du Cancer·D Chassoux, J C Salomon
Feb 1, 1976·Journal of the National Cancer Institute·G L BartlettD M Purnell
Apr 15, 1974·International Journal of Cancer. Journal International Du Cancer·R W Baldwin, M J Embleton
Jul 15, 1969·International Journal of Cancer. Journal International Du Cancer·R W Baldwin, M J Embleton
May 15, 1966·International Journal of Cancer. Journal International Du Cancer·R W Baldwin

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Citations

Sep 15, 1979·International Journal of Cancer. Journal International Du Cancer·N WillmottR W Baldwin

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