BCG vaccination in low birth weight newborns: analysis of lymphocyte proliferation, IL-2 generation and intradermal reaction to PPD

Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
A A FerreiraM F Ferreira

Abstract

To study vaccinal scar formation and post-vaccinal immune response in newborns with birth weight ranging from 2000 to 2499 g vaccinated in the first week of life with intradermal bacille Calmette-Guérin (BCG) (Moreau-Rio de Janeiro strain). Specific immune response to PPD was assessed in 30 low birth weight newborns (mean birth weight = 2311.7 +/- 122.1 g; mean gestational age = 38.1 +/- 1.8 weeks) in comparison to 56 control infants (mean birth weight = 3198.9 +/- 267.2 g; mean gestational age = 38.5 +/- 1.2 weeks. Low birth weight infants have an efficient immune response to vaccinal stimulus when compared to control infants as judged by specific in vitro lymphocyte proliferation (mean SI = 9.7 +/- 12.9 vs SI = 8.8 +/- 10.0, P = 0.72) and IL-2 production (mean SI = 3.1 +/- 3.4 vs SI = 2.6 +/- 2.0, P = 0.38). Intradermal reaction to PPD was also comparable in both groups (mean induration diameter = 9.5 +/- 5.1 mm vs 9.6 +/- 5.0 mm, P = 0.94). These data suggest that low birth weight newborns show a good immune response to BCG, thus reinforcing the inclusion of such infants in regular vaccination programs with intradermal BCG.

References

Sep 1, 1990·Tubercle·M R Sedaghatian, I A Shana'a
Oct 1, 1989·The American Review of Respiratory Disease·H F PabstM Grace
Jul 1, 1985·Acta paediatrica Scandinavica·A H Dawodu
Mar 1, 1983·Tubercle·G R de SouzaN M Bethlem

❮ Previous
Next ❯

Citations

Jun 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·S Thayyil-SudhanA K Deorari
Apr 13, 2006·Expert Review of Vaccines·Adam RothP Aaby
Aug 20, 2015·Journal of Family Medicine and Primary Care·Sara S DhanawadeVijay N Patil
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Carlos A Cuello-GarcíaCarlos Jiménez Gutiérrez
Jun 15, 2004·The Pediatric Infectious Disease Journal·Adam RothPeter Aaby
May 26, 2009·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Patrícia Marques RodriguesEthel Leonor Noia Maciel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

International Braz J Urol : Official Journal of the Brazilian Society of Urology
Francisco P FonsecaAdemar Lopes
Ocular Immunology and Inflammation
T TanakaM Usui
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
F OkanA Nuhoglu
Zhonghua er ke za zhi. Chinese journal of pediatrics
Hui-min LiZai-fang Jiang
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
I DouradoM L Barreto
© 2021 Meta ULC. All rights reserved