BCG vaccine for immunotherapy in warts: is it really safe in a tuberculosis endemic area?

Dermatologic Therapy
Deepashree DaulatabadArchana Singal

Abstract

Management of recurrent and or recalcitrant warts can be a therapeutic challenge and in such cases invoking body's own immunity may help to overcome the present episode and also prevent recurrences. Bacilli Calmette Geurin (BCG) immunotherapy has long been considered to be an effective and safe modality in such cases. We present a series of seven cases treated with BCG immunotherapy wherein a single dose of BCG caused regression of wart in 85.7% patients and complete resolution was evident in 28.6% patients. However, the development of adverse effects precluded any further dosages in four of seven (57.1%) patients. This raises serious concern on the safety of this therapeutic modality, especially in a population endemic to tuberculosis.

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References

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Jan 11, 2007·Clinical Medicine & Research·Michelle M Lipke
Apr 22, 2011·Indian Journal of Dermatology, Venereology and Leprology·Laxmisha Chandrashekar
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Feb 28, 2015·Journal of Cutaneous and Aesthetic Surgery·Piyush Kumar, Anupam Das

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Citations

Oct 13, 2016·Indian Dermatology Online Journal·Devinder M Thappa, Minu J Chiramel
Mar 3, 2020·The Journal of Dermatological Treatment·Kanchana LeerunyakulSuthinee Rutnin
Mar 5, 2021·AIMS Microbiology·Oluwafolajimi A AdesanyaChibuike J Chukwudike
Apr 2, 2021·Infection and Drug Resistance·Gopala KoneruHelal F Hetta
May 8, 2021·International Reviews of Immunology·Ashok AspatwarSeppo Parkkila
Jun 2, 2021·The Journal of Clinical Investigation·Alok K SinghWilliam R Bishai

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