PMID: 12788671Jun 6, 2003Paper

BCL-2 and BAX expression and cell proliferation, after partial hepatectomy with and without ischemia, on cholestatic liver in rats: an experimental study

The Journal of Surgical Research
Dionissios D KaraviasDionissis S Bonikos

Abstract

Liver regeneration after partial hepatectomy (PHx) is regulated by several factors that activate or inhibit hepatocyte proliferation. Apoptosis seems to play an important role in cellular proliferation and liver regeneration. This study investigates the expression apoptosis-associated genes bcl-2 and bax, and the presence of apoptosis and cell proliferation after PHx, in normal and jaundiced rats with or without superimposed ischemia. The study included 50 male Wistar rats assigned into; five groups (10 rats each). On day 0, rats of groups II, IV, and V underwent common bile duct ligation (BDL). On day 10, total liver ischemia (TLI) (occlusion of hepatic artery and portal vein-TLI) for 30 min was performed on animals of group V. When TLI was completed, all 30 animals (of groups I, IV, and V) underwent PHx (68%). Animals of group III underwent only TLI for 30 min. Rats of groups I, IV, and V were sacrificed 24 and 48 h after PHx was completed. Rats of group II were sacrificed 10, 11, and 12 days after BDL. Rats of group III were sacrificed immediately, 24 and 48 h after TLI completion. Liver tissue was obtained and pathologic examination included: (a) H&E stain, (b) in situ hybridization (detection of bcl-2 and bax mRNA) in para...Continue Reading

References

Mar 1, 1995·The Journal of Surgical Research·H MaruyamaH Takagi
May 1, 1996·Seminars in Surgical Oncology·T KurokawaH Takagi
Jan 1, 1997·Archives of Pathology & Laboratory Medicine·D W Ross
Jun 2, 1998·Seminars in Liver Disease·G FanC J Steer
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SakamotoA J Demetris
May 21, 1999·Virchows Archiv : an International Journal of Pathology·B J StähelinJ Reichen
Jan 5, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M FiorentinoW F Grigioni
Sep 28, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S SalakouD Dougenis
Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·E GiannopoulouE Papadimitriou

❮ Previous
Next ❯

Citations

Oct 16, 2003·The Journal of Surgical Research·David W McFadden
Dec 20, 2011·World Journal of Gastrointestinal Pathophysiology·Stelios F AssimakopoulosChrisoula D Scopa
Jul 10, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Athanassios C TsamandasHaralabos P Kalofonos

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Scandinavian Journal of Gastroenterology
V E EysseleinH Goebell
Liver International : Official Journal of the International Association for the Study of the Liver
Athanassios C TsamandasCharalambos A Gogos
© 2022 Meta ULC. All rights reserved