Bcl-2 and Bax expressions in pre-term, term and post-term placentas

American Journal of Reproductive Immunology : AJRI
Silvia DaherEstela Bevilacqua

Abstract

Placental apoptosis-associated protein imbalance might contribute to the pathogenesis of pre- and post-term birth. Therefore, we evaluated the expression and distribution of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) molecules in term, pre-term and post-term placentas. Placental samples were collected from women with term (n = 25), pre-term (n = 7) and post-term (n = 10) deliveries. The expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens. The pattern of immunostaining for Bcl-2 and Bax was the same in all samples, but not the intensity. The Bax/Bcl-2 ratio was higher in both pre-term and post-term placental samples compared with term placentas as a result of intense reactivity for the pro-apoptotic factor, Bax in pre-term and post-term placentas and, for Bcl-2 decrease in pre-term placentas. These findings suggest that different unbalance mechanisms in placental apoptotic-associated protein expressions may be involved in the physiopathology of pre-term and post-term births.

References

Jul 1, 1997·American Journal of Obstetrics and Gynecology·S C SmithE M Symonds
May 16, 1998·International Journal of Cancer. Journal International Du Cancer·N SakuragiS Fujimoto
Apr 14, 1999·Cell Death and Differentiation·H PerlmanR Buttyan
Aug 31, 2000·Gynecologic and Obstetric Investigation·R HalperinD Schneider
Jun 16, 2001·American Journal of Obstetrics and Gynecology·S J Fortunato, R Menon
Feb 23, 2002·The Histochemical Journal·M De FalcoA De Luca
Jun 14, 2002·International Journal of Oncology·Darja KanducEmanuel Farber
Mar 28, 2006·Diabetes Research and Clinical Practice·Fabio SgarbosaMarilza V C Rudge

❮ Previous
Next ❯

Citations

Apr 25, 2012·Acta Obstetricia Et Gynecologica Scandinavica·Csaba DemendiJózsef Gábor Joó
Jul 9, 2010·Anatomia, histologia, embryologia·S SoniA K Jain
Oct 9, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Balázs BörzsönyiJózsef Gábor Joó
Sep 11, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Csaba DemendiJózsef Gábor Joó
May 5, 2012·Reproductive Sciences·Michela TorricelliFelice Petraglia
Mar 11, 2011·Journal of Immunoassay & Immunochemistry·Magdalena Orczyk-PawiłowiczIwona Kątnik-Prastowska
Apr 28, 2020·American Journal of Perinatology·Hector Mendez-FigueroaSuneet P Chauhan
Oct 8, 2021·Systems Biology in Reproductive Medicine·Prachi Pathare-Ingawale, Preeti Chavan-Gautam

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis