PMID: 7524704Jan 1, 1994Paper

Bcl-2 and Fas, molecules which influence apoptosis. A possible role in systemic lupus erythematosus?

Autoimmunity
L M RoseD A Isenberg

Abstract

Polyclonal B cell activation and the production of antibodies against a variety of autoantigens are features of systemic lupus erythematosus (SLE). Autoreactive B cells are found in healthy individuals but their numbers are probably regulated by cell death, after a few days, in the absence of proliferative stimuli. The process which achieves this regulation is known as apoptosis or programmed cell death. It has been postulated that in SLE patients dysfunction of apoptosis could result in the inappropriate longevity of autoreactive B cells, allowing autoantibody levels to reach pathogenic thresholds. This hypothesis has arisen as a result of studies revealing links between autoimmunity and two molecules which influence apoptosis. These are bcl-2 which enhances cell survival by inhibiting or delaying apoptosis and Fas, a cell surface molecule involved in the induction of apoptosis. Transgenic mice over expressing bcl-2 in their B cells showed polyclonal B cell expansion and their B cells showed extended survival in vitro. After a few months these mice developed an autoimmune syndrome resembling SLE. Mice that carry the lpr disorder have defects in the Fas gene. These mice, which do not express functional Fas molecules, suffer fro...Continue Reading

References

Oct 8, 1992·Nature·R P BissonnetteD R Green
Dec 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P MonaghanM F Greaves
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M KatsumataJ C Reed
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E S AlnemriG Litwack
Apr 3, 1992·Cell·G I EvanD C Hancock
Jan 1, 1991·The Journal of Experimental Medicine·K MatsumotoK Nomoto
Jul 1, 1990·Tissue Antigens·E A Clark
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D M HockenberyS J Korsmeyer
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A StrasserA W Harris
Aug 1, 1991·Immunological Reviews·A BastenC C Goodnow
Dec 21, 1989·Nature·Y J LiuI C MacLennan
Dec 1, 1987·The Journal of Pathology·A H Wyllie
Nov 1, 1987·The Journal of Clinical Investigation·W B GraningerS J Korsmeyer
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y Tsujimoto, C M Croce
Jan 1, 1986·Scandinavian Journal of Rheumatology·A Wangel
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Aug 1, 1993·The Journal of Experimental Medicine·J WuJ D Mountz
Aug 26, 1993·Nature·J OgasawaraS Nagata
Jan 28, 1993·Nature·M D JacobsonM C Raff

❮ Previous
Next ❯

Citations

May 26, 1999·Survey of Ophthalmology·E M Messmer, C S Foster
Sep 1, 1996·The Journal of Clinical Investigation·J WuJ D Mountz
Oct 2, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Eyad Alsaeed
Oct 17, 2015·International Journal of Molecular Sciences·Barbara Stypińska, Agnieszka Paradowska-Gorycka
Dec 21, 2010·Clinical Oncology : a Journal of the Royal College of Radiologists·C E LeeN J Slevin
Nov 3, 2009·Lupus·G Domenico Sebastiani, M Galeazzi
Oct 13, 2006·Clinical and Experimental Immunology·N A FathiN A Afifi
Apr 5, 1997·Annals of the New York Academy of Sciences·S NisitaniT Honjo
Mar 14, 1998·American Journal of Clinical Oncology·S M Rakfal, M Deutsch
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephanie AtencioBrian L Kotzin
May 29, 1998·European Journal of Immunology·Y MunakataT Sasaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.