PMID: 9416483Jan 7, 1998Paper

bcl-2 and p53 immunophenotypes in pre-invasive, early and advanced oesophageal squamous cancer

Histopathology
A R ParentiV Ninfo

Abstract

An inverse correlation between bcl-2 and p53 expression has been reported in several types of epithelial tumour. The role of bcl-2 and p53 in the development of oesophageal squamous carcinoma has yet to be established. The expression of bcl-2 and p53 proteins has been evaluated in the multistage oesophageal tumorigenesis, which progresses from normal mucosa to dysplasia (squamous intraepithelial lesion, SIL), to invasive early and advanced oesophageal squamous cancer. Sixty-four cases of squamous oesophageal cancer, coexisting with SIL in 18 cases, were immunohistochemically analysed for any overexpression of bcl-2 and p53 proteins. Any association of bcl-2 and p53 protein expression with patient survival was also analysed. We observed bcl-2 expression that decreased significantly during the progression of oesophageal carcinogenesis. A decreasing frequency in the expression of bcl-2 in advanced oesophageal squamous cancer coincided with frequent p53 overexpression. bcl-2 expression was correlated with patient survival by univariate analysis. The association disappeared after adjusting for tumour stage, p53 overexpression showed no association with patient survival by either univariate or multivariate analysis. The down-regulati...Continue Reading

Citations

Jul 3, 2013·Best Practice & Research. Clinical Gastroenterology·Michio ShimizuGregory Y Lauwers
Jun 2, 2005·The Surgical Clinics of North America·King F Kwong
Mar 29, 2000·Critical Reviews in Oncology/hematology·A K Lam
Sep 5, 2009·BMC Cancer·Mikiko TakikitaStephen M Hewitt
Oct 10, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·E J GarciaC Cohen
May 12, 2012·Journal of Gastroenterology·Eisuke ItoHiroyasu Makuuchi
Sep 18, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E ItoH Makuuchi
Mar 17, 2010·Arquivos De Gastroenterologia·Dárcio Matenhauer LehrbachVenâncio Avancini Ferreira Alves
Feb 24, 2001·Journal of Endodontics·A PiattelliP De Fazio
Sep 25, 2004·Archives of Pathology & Laboratory Medicine·Tie-Jun LiShu-Yuan Xiao
Aug 27, 2005·Archives of Pathology & Laboratory Medicine·Lourenco SbragiaJoaquim Bustorff-Silva

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