Bcl-2 expression in a papillary tumor of the pineal region

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Michelle Fèvre-MontangeAnne Jouvet

Abstract

Neuroepithelial papillary tumor of the pineal region (PTPR) has been described by several groups and recognized by the 2007 World Health Organization Classification of Tumors of the Central Nervous System. The proto-oncogen Blc-2 can function as an apoptosis suppressor and can promote neoplastic transformation. It may also be involved in neuroendocrine differentiation in some tumors. As PTPRs express neuroendocrine markers, we investigated the expression of Bcl-2 in tumoral cells of a new case of PTPR in a 42-year-old woman. Bcl-2 immunostaining was detected in the cytoplasm of the tumoral cells; staining intensity was heterogeneous from cell to cell and more intense in papillary areas. This intense expression of Bcl-2 in one case of PTPR with a high proliferation index (8%) might be related to the malignancy of this neoplasm. It will be interesting to investigate the prognosis impact of Bcl-2 expression in a large series of PTPRs.

References

Mar 27, 2003·The American Journal of Surgical Pathology·Anne JouvetMichelle Fèvre-Montange
Oct 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Josef ZamecnikRoman Kodet
Jun 29, 2004·Acta Neuropathologica·Junji ShibaharaMasashi Fukayama
Apr 28, 2006·Neuropathology and Applied Neurobiology·M HasselblattW Paulus
Oct 6, 2006·Journal of Neuropathology and Experimental Neurology·Michelle Fèvre-MontangeAnne Jouvet
Apr 27, 2007·Neurosurgery·Elias DagnewFranco DeMonte
Aug 11, 2007·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Wiesław MarcolMarcin Roszkowski
Dec 12, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tibor BocoElizabeth Cochran
Dec 27, 2007·Neurologia Medico-chirurgica·Ichiro KawaharaTomayoshi Hayashi

❮ Previous
Next ❯

Citations

Nov 30, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A SantoroM Salvati
Jun 11, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Katherine PoulgrainQueenie Lau
Oct 15, 2010·Neuropathology and Applied Neurobiology·E Lechapt-ZalcmanA Jouvet

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis