bcl-2 expression, p53 accumulation, and apoptosis in ovarian carcinomas

American Journal of Clinical Pathology
J DieboldU Löhrs

Abstract

Because little is known about the importance of apoptosis and its regulation in epithelial ovarian cancer, the authors looked for bcl-2 expression and p53 accumulation by immunohistochemistry in 148 ovarian carcinomas of different histologic types and stages. The number of apoptotic cells was assessed in situ by enzymatic detection of DNA fragmentation. Strong bcl-2 expression correlated with low histologic grade (P = .004) and was most often seen in endometrioid carcinomas (P = .001), whereas p53 accumulation was predominantly found in serous and undifferentiated carcinomas (P <.001) and high grade tumors (P <.001). p53 accumulation was associated with advanced tumor stage (P <.001) and the presence of residual disease after surgery (P <.001). Apoptosis increased with histologic grade (P = .012); apoptotic cells were sparse or absent in tumors of low malignant potential and mucinous carcinomas, but found in all other carcinoma types (P = .001). Apoptosis, bcl-2 expression, and p53 protein accumulation were not correlated with each other. The analysis of the postoperative course of 110 patients showed that survival depended on histologic tumor type (P = .0037), histologic grade (P = .0143), FIGO (International Federal of Gyneco...Continue Reading

Citations

Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BaekelandtG B Kristensen
Jul 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R VangM T Deavers
Dec 6, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F M Muggia
Mar 22, 2006·Journal of Surgical Oncology·Gamal H EltabbakhKumarasen Cooper
May 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Suniti K Mishra, Julian A Crasta
Jul 30, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Estrid V S HøgdallClaus K Høgdall
Mar 16, 2000·Thyroid : Official Journal of the American Thyroid Association·T T SreelekhaM R Pillai
Jun 20, 2003·Molecular Pharmacology·Cristiano FerliniGiovanni Scambia
Jul 9, 2008·World Journal of Gastroenterology : WJG·Hong-Yi CaiZhi-Yan Zhang
Apr 19, 2013·Journal of Cancer Research and Clinical Oncology·Linjuan XuZehua Wang
Mar 13, 2008·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J E PalmerT P Rollason
Feb 18, 2003·Pathology International·Eun-Ik SonSang-Pyo Kim
Jan 21, 2016·Oncology Letters·Rina KatoIchio Fukasawa
Jul 9, 1998·Pathology Oncology Research : POR·R PettyI Cree
Jun 13, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I SkirnisdóttirB Sorbe
Jan 5, 2002·Applied Immunohistochemistry & Molecular Morphology : AIMM·C D ScopaA C Tsamandas
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I SkírnisdóttirB Sorbe
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M BaekelandtR Holm
May 16, 1998·International Journal of Cancer. Journal International Du Cancer·N SakuragiS Fujimoto
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L-M ChenB Y Karlan
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kentaro NakayamaYuji Takebayashi
Feb 27, 2021·Journal of Theoretical Biology·Chong YuJin Wang
Feb 13, 2001·Gynecologic Oncology·E S HoF S Liu
Jul 3, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H W NijmanC J Meijer
Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y ManoI Nagata
Sep 19, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Jin Q ChengBenjamin K Tsang
Oct 27, 2009·Journal of Ovarian Research·Nicole S AndersonPatricia A Kruk

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
R M KatsoT S Ganesan
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
I SkirnisdóttirT Seidal
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
R A M SagarraS F M Derchain
© 2021 Meta ULC. All rights reserved