BCL-2 family isoforms in apoptosis and cancer

Cell Death & Disease
Chloe F A WarrenNikola A Bowden

Abstract

The BCl-2 family has long been identified for its role in apoptosis. Following the initial discovery of BCL-2 in the context of B-cell lymphoma in the 1980s, a number of homologous proteins have since been identified. The members of the Bcl-2 family are designated as such due to their BCL-2 homology (BH) domains and involvement in apoptosis regulation. The BH domains facilitate the family members' interactions with each other and can indicate pro- or anti-apoptotic function. Traditionally, these proteins are categorised into one of the three subfamilies; anti-apoptotic, BH3-only (pro-apoptotic), and pore-forming or 'executioner' (pro-apoptotic) proteins. Each of the BH3-only or anti-apoptotic proteins has a distinct pattern of activation, localisation and response to cell death or survival stimuli. All of these can vary across cell or stress types, or developmental stage, and this can cause the delineation of the roles of BCL-2 family members. Added to this complexity is the presence of relatively uncharacterised isoforms of many of the BCL-2 family members. There is a gap in our knowledge regarding the function of BCL-2 family isoforms. BH domain status is not always predictive or indicative of protein function, and several ot...Continue Reading

References

Oct 8, 1992·Nature·R P BissonnetteD R Green
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M KatsumataJ C Reed
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·E S AlnemriG Litwack
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y Tsujimoto, C M Croce
Jun 21, 1985·Science·Y TsujimotoC M Croce
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KozopasR W Craig
Mar 15, 1996·The Journal of Biological Chemistry·A J MinnC B Thompson
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·S L SchendelJ C Reed
Jan 7, 1998·Oncogene·A BehamT J McDonnell
Jul 24, 1998·Biochemical and Biophysical Research Communications·J BanE Tschachler
Feb 18, 1999·The Journal of Clinical Investigation·A Z BadrichaniC Ferran
Feb 26, 1999·The Journal of Biological Chemistry·B A FroeschJ C Reed
Jul 20, 1999·The Journal of Biological Chemistry·D G KirschJ M Hardwick
Sep 22, 1999·Molecular and Cellular Biology·B S ChangC B Thompson
Apr 15, 2000·The Journal of Biological Chemistry·C D BingleM K Whyte
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·J L WangZ Huang
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·A M PetrosS W Fesik
Jun 13, 2001·The Journal of Cell Biology·A NechushtanR J Youle
Jun 20, 2001·Nature Reviews. Molecular Cell Biology·J C Martinou, D R Green
Aug 27, 2002·International Journal of Radiation Biology·C Belka, W Budach
Mar 5, 2004·Biochimica Et Biophysica Acta·Andrew M PetrosStephen W Fesik
Sep 21, 2004·Breast Cancer Research and Treatment·Laura EspañaAngels Sierra
Oct 9, 2004·The Journal of Biological Chemistry·Cynthia A MassaadGiulio Taglialatela
Nov 20, 2004·The Journal of Biological Chemistry·Catherine L DayMark G Hinds
Dec 31, 2004·Cell Research·Chang You LiJiu Yong Xie
Apr 30, 2005·Cell Death and Differentiation·L LindenboimR Stein
May 20, 2005·Nature·Tilman OltersdorfSaul H Rosenberg
Sep 24, 2005·Cell·Sophie PattingreBeth Levine
Sep 24, 2005·Nature Cell Biology·Carl WhiteJ Kevin Foskett

❮ Previous
Next ❯

Citations

Apr 24, 2020·Journal of Cellular Physiology·Suzanne EstaphanEnas Ahmed Mohamed
Jun 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cristian ScheauMonica Neagu
Apr 23, 2020·Cell Death & Disease·Mariusz L Hartman, Malgorzata Czyz
Apr 17, 2020·Expert Opinion on Biological Therapy·Adrian PelinRagunath Singaravelu
Oct 6, 2020·Journal of Oncology·Amir R AfshariAmirhossein Sahebkar
Aug 1, 2019·Experimental and Therapeutic Medicine·Wenwen ZhouYanhong Yang
Apr 16, 2020·Cancers·Magdalena Klanova, Pavel Klener
Sep 11, 2020·Clinical and Experimental Reproductive Medicine·Reyhane VardiyanAlireza Talebi
Jan 16, 2020·International Journal of Molecular Sciences·Consuelo BorrásJosé Viña
Apr 23, 2020·International Journal of Molecular Sciences·Ester SaavedraFrancisco Estévez
Nov 6, 2020·Drug and Chemical Toxicology·Chiagoziem A Otuechere, Ebenezer O Farombi
Nov 21, 2020·Natural Product Research·Archana BhumireddyKrishna Satya Alapati
Dec 9, 2020·Phytotherapy Research : PTR·Cijo George VazhappillyRajan Radhakrishnan
Jan 13, 2021·Seminars in Cancer Biology·Alfonso Varela-LópezJosé L Quiles
Jan 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zohreh SalariFatemeh Sharifi
Jul 11, 2020·Current Topics in Medicinal Chemistry·Ghazala ButtBaojun Xu
Jan 24, 2021·Scientific Reports·Hadi TavakkoliAlireza Keyhani
Nov 18, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mingxue LiHua Li
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jing ZhangHong Ji
Mar 2, 2021·Pathology, Research and Practice·Zhi Xiong ChongWan Yong Ho
Mar 11, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tuyelee DasAbhijit Dey
Mar 1, 2021·Protein Science : a Publication of the Protein Society·David A PriceSean D Moran
Mar 13, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Manon CallensTim Vervliet
Aug 20, 2020·Seminars in Cancer Biology·Amir R AfshariAmirhossein Sahebkar

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
antisense oligonucleotides

Clinical Trials Mentioned

NCT02920697
NCT02920541
NCT02603445
NCT02979366

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Current Cancer Drug Targets
Rami Z MorsiGhassan Dbaibo
American Journal of Physiology. Cell Physiology
Eva SzegezdiAfshin Samali
International Journal of Cancer. Journal International Du Cancer
Tsukasa Shibue, Tadatsugu Taniguchi
© 2022 Meta ULC. All rights reserved